Term
| What is Raynaud's disease? |
|
Definition
| Decreased blood flow to fingers or toes in response to cold temp or emotional stress (turn white) |
|
|
Term
| What is Raynaud's phenomenon? |
|
Definition
| Raynaud's disease secondary to a mixed connective tissue disease, SLE, or CREST syndrome |
|
|
Term
Temporal (giant cell) arteritis:
- Who
- Cause
- 4 Symptoms |
|
Definition
Who: elderly
Cause: focal granulomatous inflammation in branches of the carotid artery
Symptoms: unilateral headache, jaw claudication, irriversible blindness, polymyalgia rheumatica |
|
|
Term
Takayasu's arteritis:
- Who
- Cause
- 6 Symptoms |
|
Definition
Who: Young asian females
Cause: granulomatous thickening of aortic arch proximal to great vessels
Symptoms: weak upper extremity pulses (pulseless), fever, night sweats, arthritis and myalgias, skin nodules, ocular problems |
|
|
Term
Polyarteritis nodosa:
- Who
- Cause
- 3 Symptoms |
|
Definition
Who: young adults
Cause: immune complex mediated transmural fibrinoid necrosis of renal and visceral vessels (NOT lung)
Symptoms: depends on where it is, but hypertension, neuro dysfunction, cutaneous eruptions |
|
|
Term
Kawasaki disease:
- Who
- 6 Symptoms |
|
Definition
Who: Asian kids <4
Symptoms:
Fever
lymphadenitis
conjunctivitis
strawberry tongue
hand-foot erythema
desquamation |
|
|
Term
Buerger's disease (thromboangiitis obliterans):
- Who
- Cause
- 2 Symptoms |
|
Definition
Who: young men who are heavy smokers
Cause: segmental thrombosing vasculitis
Symptoms: Raynaud's phenomenon, intermittent claudication leads to gangrene of digits |
|
|
Term
Microscopic polyangiitis:
- Cause
- 2 Symptoms
- 2 Lab findings |
|
Definition
Cause: immune
Symptoms: glomerulonephritis, palpable purpura
Labs: no granulomas, p-ANCA |
|
|
Term
Wegener granulomatosis:
- Cause
- Symptoms
- 2 lab findings |
|
Definition
Cause: necrotizing vasculitis and necrotizing granulomas
Symptoms: upper respiratory, lower respiratory, and renal involvement
Labs: c-ANCA, large nodular densities on CXR |
|
|
Term
Churg-Strauss syndrome:
- Who
- Cause
- 4 Symptoms
- 2 lab findings |
|
Definition
Who: Asthma patients
Cause: immune- granulomatous vasculitis with eosinophilia
Symptoms: sinusitis, palpable purpura, peripheral neuropathy (wrist or foot drop), can involve other organs too
Labs: p-ANCA, eosinophilia |
|
|
Term
Henoch-Schönlein:
- Who
- Cause
- 3 Symptoms |
|
Definition
Who: children
Cause: IgA immune complexes
Symptoms: palpable purpura on buttocks/legs, arthralgia, abdominal pain with melena |
|
|
Term
Sturge-Weber disease:
- Cause
- 4 Symptoms |
|
Definition
Cause: congenital vasculitis of capillaries
Symptoms: port-wine stain on face, ipsilateral leptomeningeal angiomatosis (intracerebral arteriovenous malformation), seizures, early onset glaucoma
[image] |
|
|
Term
| What are the upper respiratory symptoms in Wegener granulomatosis? (4) |
|
Definition
Perforation of nasal septum
chronic sinusitis
otitis media
mastoiditis |
|
|
Term
| What are the lower respiratory symptoms in Wegener granulomatosis? (2) |
|
Definition
Necrotizing granulomas:
hemoptysis
dyspnea |
|
|
Term
| What are the renal symptoms in Wegener granulomatosis? (2) |
|
Definition
Necrotizing glomerulonephritis:
hematuria
red cell casts |
|
|
Term
| How do you treat Wegener granulomatosis? (2) |
|
Definition
cyclophosphamide
corticosteroids |
|
|
Term
| What is the most common childhood systemic vasculitis? |
|
Definition
|
|
Term
| Which vasculitis is associated with Hep B? |
|
Definition
|
|
Term
| How do you treat Kawasaki disease? |
|
Definition
| IV immunoglobulin and aspirin |
|
|
Term
| What complication can occur in Kawasaki disease? |
|
Definition
|
|
