Term
Polycyclic aromatic hydrocarbons (PAH)
- mechanism
- disease |
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Definition
Mechanism:
- from BBQ, tobacco carcinogen is activated by cyt p450
Disease: lung and bladder cancer |
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Term
Aromatic amines and azo dyes
-mechanism
-disease |
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Definition
Activated by cyt p450; mostly toxic in liver
B-napthylamine leads to bladder cancer esp in patients working in rubber and aniline dye industries |
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Term
Aflatoxin
-mechanism
-disease |
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Definition
Produced by Aspergillus flavus (fungi)
Liver cancer in conjunction with HBV |
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Term
Alkylating agents
-mechanism
-disease |
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Definition
Chemo drugs = direct alkylating agents and cause cross-linking of guanosine bases in DNA
Therapy related leukemias |
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Term
Nitrosamines and amides
-mechanism
-disease |
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Definition
Formed in GI tract from processed foods containing nitrate perservatives that are converted by bacteria to nitrite
Contributes to gastric cancer |
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