Shared Flashcard Set

Details

Carbohydrate absorption and digestion
Medical School Biochemistry
43
Biochemistry
Graduate
09/30/2011

Additional Biochemistry Flashcards

 


 

Cards

Term
What are the metabolically important linear polysaccharides?
Definition
Cellulose and Amylose
Term
The free C4 end of a polysaccharides is what?
Definition
Non reducing end
Term
The Free C1 end of a polysaccharides is what?
Definition
Reducing end
Term
Cellulose has what kind of carbon bonding?
Definition
Beta 1-4 glycoside bonding
Term
Amylose has what kind of carbon bonding?
Definition
Alpha 1-4 glycoside bonding
Term
Amylopectin has what kind of carbon bonding?
Definition
Alpha 1-4 and Alpha 1-6 glycoside bonding
Term
The formation of an alpha 1-6 bond is indicative of what in a polysaccharide?
Definition
branching. The area of the alpha 1-6 bond is coined the branching point
Term
How many reducing and non-reducing ends does a linear polysaccharide have?
Definition
One reducing and one non-reducing end
Term
How many reducing and non-reducing ends do branched polysaccharides have?
Definition
1 reducing end and a variable amount of non-reducing ends
Term
What is the structural difference between amylopectin and glycogen?
Definition
While both are branched polysaccharides the glycogen has many more branch points and non-reducing ends
Term
What is the significance of a higher number of non-reducing ends in a branched polysaccharide?
Definition
The more branched a branched polysaccharide the faster it is metabolized
Term
Dietary starch is composed of what polysaccharides?
Definition
Amylose and Amylopectin
Term
Dietary fiber is composed of what polysaccharides?
Definition
Cellulose
Term
What enzymes work in the digestion of amylose?
Definition
alpha-amylase and maltase
Term
What enzymes work in the digestion of amylopectin?
Definition
alpha amylase, maltase, and alpha dextrinase
Term
Where does alpha amylase function?
Definition
active alpha amylase will digest polysaccharides in the mouth (within saliva) and in the duodenum of the small intestine (within pancreatic juices)
Term
How does active alpha-amylase get to the duodenum of the small intestine?
Definition
alpha-amylase is secreted by the pancrease along with other digestive enzymes and bicarb
Term
What bonds do alpha-amylase cleave?
Definition
alpha 1-4 glycoside bonds but will not cleave terminal alpha 1-4 glycoside bonds
Term
what bonds does maltase cleave?
Definition
alpha 1-4 glycoside bonds
Term
What is the product of Amylopectin cleaved by alpha amylase?
Definition
Maltose, maltriose, and alpha-dextrins
Term
What is the product of amylose cleaved by alpha-amylase?
Definition
maltose and maltotriose
Term
What is the rate-limiting step in the digestion of polysaccharides?
Definition
glucose transport
Term
What does maltase act on?
Definition
maltose (disaccharide) and maltotriose (trisaccharide)
Term
what does alpha-dextrinase act on?
Definition
the alpha-dextrins
Term
What are alpha-dextrins?
Definition
alpha-dextrins are the branch chain products of the degradation of amylopectin by alpha-amylase
Term
what bonds does alpha-dextrinase cleave?
Definition
alpha 1-4 bonds and alpha 1-6 glycoside bonds
Term
What enzymes of polysaccharide digestion are endoglycosidases?
Definition
alpha-amylase
Term
What enzymes of polysaccharide digestion are exoglycosidases?
Definition
alpha-dextrinase and maltase
Term
What are abnormally high levels of alpha-amylase in the blood indicative of?
Definition
Pancreatitis
Term
Where in the body is maltase and alpha-dextrinase found?
Definition
Brush border: epithelial cells of the intestine
Term
What is the chemical mechanism by which the alpha 1-4 and alpha 1-6 bonds are cleaved?
Definition
Hydrolysis
Term
What defines active transportation?
Definition
Transportation of substances against a concentration gradient
Term
What transporter is responsible for insulin-stimulated uptake of glucose?
Definition
Glut-4
Term
What transporter is responsible for the transport of fructose?
Definition
Glut5
Term
What tissue responds to insulin for glucose uptake?
Definition
Skeletal and cardiac muscle, adipose tissue
Term
What transporter is involved in the basal uptake of glucose and has a low Km value?
Definition
Glut1 and Glut 3. The low Km drives the preferential uptake of glucose to these cells
Term
What glucose transporter targets the liver, pancreatic beta cells, the kidney, and the small intestine?
Definition
Glut 2
Term
Glut 2 has a high Km value which means that it will absorb glucose when?
Definition
Post-prandial state
Term
What is the SGLT1? What is it's function?
Definition
Sodium linked transporter of glucose. It participates in active transport of glucose in the small intestine and kidneys
Term
What type of glucose transporters does liver have?
Definition
Glut 2
Term
What is the effect of decreased insulin on glucose transporters?
Definition
decreased the number of active Glut-4 transporters
Term
What sort of glucose transporters are found in the Kidneys?
Definition
SGLT-1 and Glut-2
Term
What sort of Glucose transporters are found in the Small Intestine?
Definition
Glut-2, Glut-5, SGLT-1
Supporting users have an ad free experience!