Term
What type of infection is Candida |
|
Definition
|
|
Term
|
Definition
|
|
Term
What do Aspergillus and Mucor infections typically result from? |
|
Definition
Breakthrough of sinus or nasal infections |
|
|
Term
Candida causes what percent of fungal infections? |
|
Definition
|
|
Term
How is Candida typically acquired? |
|
Definition
50% of humans acqurie it from their mother |
|
|
Term
Candidia infections associated with low CD4 & T lymphocyte counts cause what type of fungal infection? |
|
Definition
|
|
Term
Candida infections that result from low neutorphil counts cause what type of fungal infection? |
|
Definition
|
|
Term
True or False Yeast infections can be life threatening? |
|
Definition
|
|
Term
Candida albicans (yease infections) prefer low or high pH? |
|
Definition
|
|
Term
Name the three morphologies of C. albicans |
|
Definition
|
|
Term
Which morphologies are present during fungal infections? |
|
Definition
All three morphologies are present - Blastoconidia
- Pseudohyphae
- Germ tubes and hyphae
|
|
|
Term
Name a few types of oral candidiasis infections |
|
Definition
|
|
Term
What or the factors in the pathogenesis of oropharyngeal candidiasis? |
|
Definition
|
|
Term
What are the functions of saliva? |
|
Definition
- Phsico-mechanical - flushing of the oral cavity
- Tissue coating: lubrication and permeability barrier
- Modulation of oral flora
- Antacid and neutralization
- Regulation of Ca++ and phosphate
- Digestion
- Processing of salivary molecules
|
|
|
Term
Which host factor increases occurance of oropharyngeal candidiasis? |
|
Definition
Hyposalivation frequently caused from underlying disease or therapy |
|
|
Term
What environmental factors increase occurance of oropharyngeal candidiasis? |
|
Definition
Change in normal bacterial flora and High carbohydrate diet |
|
|
Term
How does biofilm formation by candida effect successful colonization and infection in the host? |
|
Definition
- Resistance to immune attack by humoral and cellualar factors
- Resistance to antifungal compounds
|
|
|
Term
Name the three major components of the Candida cell wall |
|
Definition
|
|
Term
What are the major target for yeast infection treatments? |
|
Definition
- Mannoprotein - function: permeability barrier and attachment
- Glucan -function: structural integrity of cell; highly porous
- Chitin - function: structural scaffold for growing bud
|
|
|
Term
What are the antifungal agents used in treatment of yeast infections? |
|
Definition
|
|
Term
Which antifungal agents are toxic? |
|
Definition
|
|
Term
Which antifungal agents have a resistance problem? |
|
Definition
|
|
Term
What are the CDC recommendations for treatment of Oropharyngeal candidiasis? |
|
Definition
|
|
Term
What is the disadvantage using Nystatin suspension for the treatment of oropharyngeal candidiasis? |
|
Definition
It loses its activity soon after preparation |
|
|
Term
Name one method to reduce the virulence of C. albicans in the animal model |
|
Definition
Replacement of dietary sugar with xylitol, a sugar substitute |
|
|
Term
What are the roles in protection against Candida? (four) |
|
Definition
- Opsonization and complement fixation
|
|
|
Term
Targeting Candida to phagocyte receptors results in what? |
|
Definition
Increased levels of phagocytosis |
|
|
Term
Targeting of C. albicans to FcyR leads to what? |
|
Definition
Intracellular organism destruction |
|
|
Term
Principal behind Photodynamic Therapy (PDT) |
|
Definition
Cells treated with photosensitizing agent undergo cell death when exposed to light |
|
|