Term
| Why do geneticists like to study Drosophila? |
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Definition
1. Their entire genome has been sequenced
2. 75-80% of human disease genes hafve homologs in Drosophila |
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Term
| What is meant by "Tumors are clonal patches" |
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Definition
| Tumor cells grow in patches and all have the same genotype, but that genotype is different from the normal surrounding cells. |
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Term
| What is the effect of too much Crumbs (Crb)? |
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Definition
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Term
| What other molecule is necessary for Crb to cause overgrowth and how was it discovered? |
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Definition
yki
Genetic screening in Drosophila |
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Term
| How do we try to translate the research performed in flies to cancer pathways for humans? |
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Definition
1. Identify candidates for drug design
2. Facilitate the development of targeted vs. general therapies
3. Genotype tumors to determine pathways and responsiveness to drugs
4. Tailor drugs to genotypes
5. Scalpel vs. Axe |
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