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Definition
| Concersion from normal cell growth to unregulated growth |
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| genes involved in normal growth and division |
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| growth-stimulating pathway |
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| activated which sends the message to stimulate growth |
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| Activated growth factor receptors activate these which signal protein kinases |
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| enzymes that activate a transcription factor |
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| molecules that activate genes to initiate cell division |
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| Growth-inhibiting pathway |
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Definition
| Normal cell division supression |
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| the molecule that activates the pathway and stimulates suppression. When these bind to a surface receptor on the cell, protein kinases activate a transcription factor which in turn activates p53 to suppress growth |
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Definition
| Aggregate of cells which has lost their ability to function properly |
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| Growth of blood cessels for the express purpose of supplying the cancer with nutrients |
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| Tightly bound capillaries around the brain that don’t let anything (drugs) across |
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Definition
| first checkpoint in the cell cycle that determines if the cell can continue dividing or not. |
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| when a cell doesn’t pass a checkpoint, it is sent to the G0 resting phase where it can’t divide. some types of cells (liver, etc) can return to G1 if they are stimulated by growth factors |
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| stops growth before the cell begins mitosis (M phase) |
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Definition
| checkpoint that makes sure the spindle fibers in the cell are connected properly |
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Definition
| a protein that attaches to cyclin dependent kinases (CDK). cyclin concentration levels act as another cell division regulator |
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Definition
| Allows a cell to pass the G2 checkpoint and enter the M checkpoint |
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Definition
| kinase that requires cyclin to function. cyclin-CDK complex is called MPF |
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| Active drug that is administered to brain |
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