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Definition
Cytotoxic drugs used for cancer therapy - all contain alkyl groups and form covalent bonds w. cell constituents (esp N7 of guanine of DNA) and so cause linking and cross-linking of DNA which inhibits DNA synthesis
e.g. cyclophosphamide, carmustine, busulfan |
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Cyclophosphamide
Carmustine
Busulfan |
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Definition
| Alkylating agents used in cancer-therapy (and severe AI-dz) -all contain alkyl groups and form covalent bonds w. cell constituents (esp N7 of guanine of DNA) and so cause linking and cross-linking of DNA which inhibits DNA synthesis |
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Anti-cancer drugs which all inhibit DNA synthesis
e.g. methotrexate, flurouracil, thioguanine |
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An antimetabolite cancer therapy drug - indirectly inhibits thymidylate synthetase, which normally synthesises thymidylate, a nucleotide and so inibits DNA synthesis
-close structural analogue of folate and so blocks dihydrofolate reductase which is necessary for the enzymes action |
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Definition
| An antimetabolite cancer therapy drug - inhibits thymidylate synthetase DIRECTLY, which normally synthesises thymidylate, a nucleotide and so inibits DNA synthesis |
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| Purine analogue antimetabolites |
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Definition
Cancer therapy drugs - block a number of steps in purine synthesis and so block DNA synthesis
e.g. thioguanine, mercaptopurine |
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Definition
| A purine analogue, antimetabolite cancer therapy drug - blocks a number of steps in purine synthesis and so DNA synt. |
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Cancer therapy drugs - inhibit topoisomerase II - results in fragmented DNA +/- RNA polymerase inhibition
e.g. doxorubicin, dactinomycin |
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| A cytotoxic antibiotic used in cancer therapy -inhibits topoisomerase II and so DNA is fragmented |
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| A cytotoxic antibiotic used in cancer therapy - inhibits topoisomerase II and so DNA is fragmented, plus inhibits RNA polymerase so blocks gene transcription |
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Used in cancer therapy
e.g. vinca alkaloids (vincristine, vinblastine), etoposide |
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Plant alkyloids used as cancer therapy - inhibit microtubule formation which is essential for spindles and chromosome separation in cell division
e.g. vincristine, vinblastine |
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Definition
| A vinca alkyloid - a plant alkyloids used as cancer therapy - inhibit microtubule formation which is essential for spindles and chromosome separation in cell division |
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Definition
| A plant alkyloid used in cancer therapy - inhibits topoisomerase II and so DNA fragmented |
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| A glucocorticoid used in cancer treatment - at high doses in decreases lymphocyte proliferation and induces apoptosis - used in treatment of lymphomas |
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