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Definition
Oncogene. Overproduced in normal form due to mutation in regulatory sequence and gene amplification.
increases the expression of many delayed response gene. |
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Definition
Proto-oncogene receptor protein
Valine to Glutamine
Causes dimerization of receptor.
Makes oncoprotein Neu a constitutively active kinase |
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Definition
| Constitutively active kinase due to Her2/Erb2 mutation |
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Proto-oncogene receptor
Deletion in domain of EGF/Her1 results in loss of domain.
Constitutive activation of Erb1 oncoprotein kinase activity |
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Definition
| constitutively active protein tyrosine kinase in Her1/EGF receptor |
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| Antibody target for ectodomains of mutated ErB2/Her2 receptor |
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| Antibody target for ectodomains of mutated EGF/Her1 receptors |
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| Tyrosine kinase inhibitor for Neu and ErbB1 oncoproteins |
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Definition
| Tyrosine kinase inhibitor for ErbB1 oncoproteins |
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Definition
| consitutively active kinase that phosphorylates Ras pathway, the PI3K-Akt/PKB pathway, the Jak/STAT pathway, and transcription factors including Jun, Myc, and NF-kB |
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Definition
| Binds to catalytic cleft of Abl tyrosine kinase domain |
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| Burkitt's lymphoma Myc gene mutation |
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Definition
Put undercontrol of immunoglobulin enhancers.
Makes abnormally high amounts of normal myc protein |
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Definition
Part of PI3K Pathway
Activates S6 Kinase
Activates eIF-4E
Activation of genes encoding ribosomal subunits |
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Definition
| Phosphorylates ribosomal protein which increases ribosomal ability to translate mRNA's encoding for ribosomes |
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Definition
Platelet Derived Growth Factor
stimulate many cell types to divide, such as fibroblasts (wound healing), smooth muscle cells and glial cells |
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Definition
Epidermal Growth Factor
stimulates division of epithelial and non-epithelial cells |
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Definition
| stimulates proliferation of red blood cell precursors only |
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Definition
Transforming Growth Factor Beta
Inhibits proliferation of several cell types by blocking cell progression or stimulating cell death
Promotes p15 synthesis
Promotes PA1 expression |
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Definition
Serine/Threonine Kinases
Send signals from cell clock.
Activity depends on cyclins |
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Term
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Definition
| Regulatory/Activating unit of CDK |
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Term
| PSTAIRE alpha-helix domain |
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Definition
| present in all CDKs and is essential for binding of cyclins |
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Definition
CDK-activating kinase
Phosphorylates threonine on activation loop of CDK |
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| The type of CDK each cyclin binds with |
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Definition
D Cyclins: CDK4/6
E Cyclins: CDK2
A Cyclins: CKD2/1
B Cyclins: CDK1 |
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Definition
inhibiting the D-CDK4/6 complexes that are active in early and mid-G1
Consist of p15, p16, p18, p19 |
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Definition
Inhibit the remaining cyclin-CDK complexes that are active throughout the cell cycle
Consist of p21, p27, p57 |
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Definition
PROMOTE formation of D-CDK4/6 complexes during the G1 phase.
Inhibit E-CDK2 complexes. |
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Definition
Bind p21 and p27 to allow E-CDK2 to become active
Hypophosphorylate Rb protein |
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Definition
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Definition
Binds and inhibits E2F
Acts as repressor of proteins needed for DNA synthesis
Haplosufficient |
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Definition
| Transcription factors for genes of Cyclin A, Cyclin E, replication proteins, and itself. |
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Definition
| GTPase that activates MAP Kinase Cascade leading to expression of immediate early genes such as Myc |
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Definition
Ras guanine nucleotide exchange factor.
Binds to two SH3 domains of GRB2 and is activated when the RPTK is phosphorylated.
Removes GDP from Ras. |
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Definition
| Bridging protein with two SH3 domains bound to Sos and SH2 domain bound to phosphotyrosine on RPTK |
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Definition
| Alternative bridging protein with SH2 domain binding to RPTK and also binding to GRB2 through its own phosphorylation |
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Definition
Bcl-2-associated death promoter.
Pro-apoptotic
Inhibited by Akt/PKB |
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Definition
serine/threonine protein kinase of Beta-Catenin
antagonist of expression of growth-promoting proteins such as cyclin D1 and Myc |
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Definition
| Activates Ral-A and Ral-B |
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| Ral-A and Ral-Bactivate a number of downstream pathways |
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Definition
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Definition
| enable cellular motility through their effects on the actin cytoskeleton. |
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Definition
Transduces TGFBeta signaling
Promotes expression of p15 |
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Definition
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Plasminogen Activator Inhibitor 1
Reduces degradation of ECM by plasmin
Stops cell movement |
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Definition
| HPV Protein that binds to Rb and prevents it from binding E2F |
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Definition
Stimulates transcription of p21
Induce expression of Fas receptor
Induce expression of IGFBP-3
Induce expression of Bax
Haplo-insufficient |
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Definition
| CDK Inhibitor that binds to A-CDK1/2 and E-CDK2 |
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Definition
| Phosphorylate Chk1, Chk2, and p53 |
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Definition
Phosphorylates p53
Phosphorylates Cdc25 |
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Definition
Phosphorylates p53
Phosphorylates Cdc25 |
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Definition
| Ubiquitin ligase that binds to unphosphorylated p53 and marks it for degradation |
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Definition
| Protein phosphatase that activates A/B-CDK1 |
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Definition
| Protein phosphatase that activates E/A-CDK2 |
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Definition
Binds to p53 and ubiquitylates it.
p53 is then degraded |
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Definition
| Protein that keeps Mdm2 in the nucleolus away from p53 |
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Definition
covalent binding to the nitrogen on position 7 of guanine.
Forms intrastrand and interstrand crosslinks to damage DNA |
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Definition
| Death ligand and receptor. |
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Definition
| pro-apoptotic Bcl-2 related protein, which causes the release of cytochrome c and other proteins from the mitochondria |
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Definition
| Bind to its receptor to cause release of anti-apoptotic signals in the cell. |
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Definition
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| antagonist of NFkB, a transcription factor that stimulates for instance expression of XIAP and Bcl-2 gene products |
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Definition
Tumor suppressor
Haplo-Insufficient |
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Definition
| Ligand for Wnt signaling pathway |
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Definition
Scaffold protein that allows for GSK3 phosphorylation of Beta-Catenin when no Wnt is present.
In the presence of Wnt, binds to the LRP. |
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Definition
| Phosphorylates Beta-catenin leading to its degradation. Needs to be in complex with Axin. |
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Definition
| Transcription factor in Wnt pathway. Promotes transcription when Beta-Catenin is present due to Wnt binding |
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Definition
hypoxia inducible factor 1a
gene repressed by oxygen and induced when oxygen drops below 3-5% |
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Definition
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| Angiogenic factors produced by cancer cell |
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| Antibody that binds and neutralizes VEGF |
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Definition
| Target the intracellular kinase activity of VEGF receptor |
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