Term
This Drug only works on G2 phase of the cell cycle |
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Definition
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Term
Which cells are most effected by cancer drugs |
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Definition
Rapid proliferating cells Bone marrow GI tract Mucosa Hair Follicles Gonads |
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Term
Drugs with Renal Toxicity |
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Definition
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Term
Drugs that are Hepatotoxic |
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Definition
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Term
Pulmonary Toxic drugs (fibrosis) |
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Definition
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Term
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Definition
Doxorubicin, daunorubicin |
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Term
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Definition
Vincristine (peripheral neuropathy) |
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Term
Acoustic Nerve damage drugs |
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Definition
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Term
Major immunosuppressive drugs |
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Definition
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Term
Drugs which cause hemorrhagic cystitis |
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Definition
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Term
Drug which causes pancreatitis |
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Definition
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Term
Drug is a folic acid analog that inhibits dihydrofolate reductase-> decreases protein synthesis |
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Definition
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Term
Other uses for methotrexate besides cancer |
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Definition
Abortion, extopic pregnancy, RA, psoriasis |
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Term
Rescue drug for Methotrexate |
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Definition
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Term
Pyrimidine analog bioactivated to 5F-dUMP, which covalently complexes folic acid to decrease thymidylate sythase |
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Definition
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Term
What antifungal medication is turned into 5-flourouracil |
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Definition
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Term
Rescue for 5-flourouracil tx |
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Definition
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Term
Purine analog activated by HGPRTase |
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Definition
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Term
Increased toxicity by allopurinal |
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Definition
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Term
Same mechanism as 6-MP but can be given with allopurinol |
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Definition
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Term
Free radicles which noncovalently intercalate DNA. Also inhibits tropoisomerase |
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Definition
Doxorubicin and Daunorubicin |
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Term
Given with Doxorubicin for cardioprotective |
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Definition
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Term
Induces free radical formation, complexes with iron and oxygen |
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Definition
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Term
Inhibits Topoisomerase II |
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Definition
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Term
Covalently x link DNA @ N7. Requires bioactivation by the liver |
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Definition
Cyclophosphamide/ifosfamide |
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Term
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Definition
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Term
Alkylates DNA with pulmonary fibrosis and hyperpigmentation |
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Definition
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Term
Alkaloids that bind to tubulinin M-phase and block polymerization of microtubules to that mitotic spindle cannot form |
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Definition
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Term
Can cause paralytic Ilieus and alopecia |
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Definition
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Term
Hyperstability polymerized microtubules in M phase so that mitotic spindles cannot brk down |
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Definition
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Term
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Definition
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Term
Inhibits ribonucleotide reductase |
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Definition
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Term
SERMS Antagonists in breast and agonists in bone and endometrium |
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Definition
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Term
SERM Used in Breast cancer |
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Definition
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Term
SERM used in osteoporosis |
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Definition
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Term
A monoclonal antibody used against HER-2 (erb-B2) a tyrosine kinase. |
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Definition
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Term
Used in CML against the philadelphia chromosome |
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Definition
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Term
Monoclonal antibody against CD20 found on most B-cells |
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Definition
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Term
This drug is an alkalating agent used in hodgkin lymphoma and may have the side effect of a leukomogenic |
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Definition
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