Term
How does the mechanism of action of methotrexate differ from 5-fluorouracil? |
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Definition
Both decrease DNA and protein synthesis; folic acid analog that inhibits dihydrofolate reductase (methotrexate) vs. pyrimidine analog that inhibits thymidylate synthase (5-FU) |
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Term
How does the body metabolize 6-mercaptopurine? |
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Definition
By xanthine oxidase; purine analog, decreases de novo purine synthesis, activated by HGPRTase |
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Term
Which anticancer drug is also often used in rheumatoid diseases as well as ectopic pregnancies? |
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Definition
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Term
For which cancers is dactinomycin particularly useful? |
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Definition
Wilm’s tumor, Ewing sarcoma, rhabdomyosarcoma, childhood tumors |
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Term
What drug forms a complex between topoisomerase II and DNA? |
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Definition
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Term
What drug alkylates DNA, toxicity is pulmonary fibrosis? |
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Definition
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Term
What drug fragments DNA and also causes pulmonary fibrosis? |
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Definition
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Term
What drug blocks purine synthesis and is metabolized by xanthine oxidase? |
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Definition
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Term
What drug cross-links DNA and is nephrotoxic and ototoxic? |
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Definition
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Term
What drug is a nitrogen mustard that alkylates DNA (an electrophile that binds DNA)? |
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Definition
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Term
What drug is a folic acid analog that inhibits dihydrofolate reductase? |
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Definition
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Term
What drug prevents tubulin disassembly? |
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Definition
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Term
What drug intercalates DNA, produces oxygen free radicals, and is cardiotoxic? |
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Definition
Doxorubicin, daunorubicin |
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Term
What drugs are DNA alkylating agents used in brain cancer? |
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Definition
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Term
What drugs prevent tubulin assembly? |
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Definition
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Term
What drug inhibits thymidylate synthase and thus cause decreased nucleotide synthesis? |
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Definition
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Term
What drug is SERM and blocks estrogen binding to ER(+) cells? |
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Definition
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Term
What drug has a mechanism similar to the antivirals acyclovir and foscarnet? |
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Definition
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Term
What drug has a mechanism similar to fluoroquinolones? |
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Definition
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Term
What drug has a mechanism similar to trimethoprim? |
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Definition
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Term
What drug is a monoclonal antibody against HER-2 (erb-B2) |
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Definition
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Term
What drug causes free radical-induced DNA strand breakage? |
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Definition
Bleomycin, doxorubicin, daunorubicin |
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Term
What drug is the inhibitor of PRPP synthetase? |
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Definition
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Term
What drug is reversible with leucovorin? |
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Definition
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Term
What is the treatment for choriocarcinoma? |
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Definition
Vincristine, vinblastine, methotrexate |
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Term
What is the treatment for AML? |
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Definition
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Term
What is the treatment for CML? |
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Definition
Busulfan, Imatinib (Gleevac) |
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Term
What prevents breast cancer? |
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Definition
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Term
What is the treatment for testicular cancer? |
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Definition
EBC (Etoposide, bleomycin, cysplatin) |
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Term
What is applied topically for AKs and basal cell cancers? |
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Definition
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Term
What is the treatment for childhood tumors (Ewing sarcoma, Wilms tumor, rhabdomyosarcoma? |
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Definition
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Term
What inhibits ribonucleotide reductase? |
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Definition
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Term
What causes a side effect of hemorrhagic cystitis? |
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Definition
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Term
What is an inhibitor of the mutated tyrosine kinase produced by the Philadelphia chromosome? |
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Definition
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Term
What are the potential side effects of prednisone use? |
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Definition
Cushingoid features, acne, cataracts, osteoporosis, hyperglycemia/DM, HTN, peptic ulcer, psychosis, insomnia |
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