Term
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Definition
Blocks DHFR; long lasting
Part of CMF |
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Term
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Definition
Incorporated in DNA and blocks DNA replication because Thymidilate Synthase cant add methyl to C5
Part of CMF |
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Term
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Definition
| Cyclophosphamide, Methotrexate, 5-Fluro-Uracil |
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Term
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Definition
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Term
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Definition
| Analog of 5-FU but replaces Cytidine |
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Term
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Definition
(Adriamycin)Topoisomerase Inhib.
Used in Breast cancer; cardiotoxic (dose dependent/ F>M) |
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Term
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Definition
| Topoisomerase Inhib. used in colorectal cancer |
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Term
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Definition
| Alkylating agent use in Lung and Ovarian cancer |
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Term
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Definition
DNA alkylating agent
Oral prodrug(no tissue damage)
May cause leukopenia or secondary cancer
Used in CMF |
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Term
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Definition
Blocks microtubule formation (Spindle poison)
may cause peripheral neurotoxicity |
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Term
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Definition
Blocks microtubule disassembly (Spindle poison)
may cause peripheral neuropathy |
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Term
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Definition
Humanized mAb against VEGF to block angiogenesis
Causes HTN (damaged endothelium)
Low efficacy so used to get cytotoxic drugs into tumor and prevent angiogenesis in macular degeneration |
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Term
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Definition
| Cyclophosphamide, Hydroxydaunorubin(Doxorubicin/Adriamycin), Oncovin(Vincristine), and Prednisone |
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Term
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Definition
Chimeric mAb against CD20 on Bcells
Improves Overall survival and disease free survival in Bcell Lymphomas when used with CHOP |
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Term
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Definition
Human mAb against EGF-R with less immunogenicity that Cetuximab
IgG2 so no C' or FcR affinity |
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Term
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Definition
Chimeric mAb against EGF-R(HER1)
Used in WT Kras Colorectal Cancer
Side effects are rash and diarrhea(EGF-R is in skin and GI tract) |
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Term
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Definition
Humanized mAb against HER2 used in agressive HER2+ breast cancers
Increases survival
Cardiotoxic (HER2 is on cardiomyocytes) |
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Term
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Definition
Chimeric mAb against CD25(IL2R)
Immunosuppressent |
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Term
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Definition
Humanized mAb against CD25(IL2R)
Immunisuppressent |
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Term
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Definition
Binds mTOR and inhibits activation of Tcells by IL2
Immunosuppressant |
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Term
| Cyclosporine and Tacrolimus |
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Definition
Bind calcineurin which inhibits IL2R and blocks Tcell proliferation
Immunosuppressant |
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Term
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Definition
Prodrug of mercaptopurine; inserts mercaptopurine in DNA and blocks replication
Immunosuppressant |
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Term
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Definition
Preotease Inhibitor that causes apoptosis
Used in Multiple Myeloma
Side affects are GI and neutropenia |
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Term
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Definition
| Broad Spectrum inhibitors mainly acting on VEGFR |
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Term
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Definition
| Broad Spectrum inhibitors mainly acting on VEGFR |
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Term
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Definition
Gleevac
Targets bcr/abl fusion protein in CML
Resistanc develops fast |
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Term
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Definition
EGFR Kinase inhibitor
Commonly used in lung cancer
Side affect is rash
Some lung cancers are resistant |
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Term
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Definition
EGFR Kinase inhibitor
Used commonly in lung cancer
Side effect is rash |
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Term
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Definition
Analgesic and Anti-inflammatory; OTC
Unstable angina/ Post MI (Because its irreversible) |
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Term
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Definition
Analgesic only; OTC
Weak base, 20%bound, weak COX-I (low AI)
No effect on uterine contractions
Safe in children, pregnancy, renal disease, asthmatics, bleeding disorders |
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Term
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Definition
Analgesic and Anti-inflammatory; OTC
Best for primary dysmenorrhea
Lowest GI risk |
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Term
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Definition
Analgesic and Anti-inflammatory; OTC
Higher ceiling and T1/2 than Aspirin |
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Term
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Definition
Analgesic and Anti-inflammatory; OTC
Higher Ceiling than Aspirin |
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Term
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Definition
Analgesic and Anti-inflammatory (salicylate)
Higher efficacy/analgesic ceiling and half life than aspirin |
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Term
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Definition
Anti-inflammatory only
Prodrug; Active sulfide metabolite
Used in renal complications |
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Term
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Definition
Anti-inflammatory only
Highest COX1-I potency
PDA in neonates
Most potent COX1 Inhib (Most POTENT AI) |
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Term
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Definition
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Term
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Definition
Anti-inflammatory only
COX2 Selective |
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Term
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Definition
Analgesic and Anti-inflammatory
COX2 Selective |
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Term
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Definition
Methylated PGE1 Analogue
Restores GI prostagladins and protects against GI sideeffects of NSAIDS |
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Term
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Definition
| Antidote to Acetaminophen poisoning |
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Term
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Definition
| Short acting glucocorticoid(8-12hrs) |
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Term
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Definition
| Short acting glucocorticoid(8-12hrs) |
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Term
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Definition
Potent mineralocorticoid
9alpha-fluoro
8-12 hrs |
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Term
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Definition
Short acting glucocorticoid
8-12hrs |
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Term
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Definition
| Intermediate acting glucocorticoid (12-36hrs) |
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Term
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Definition
Long acting glucocorticoid (36-72hrs)
A ring double bond=higher GC activity
Methyl on C6=higher GC potency and longer half life
Methyl on C16 on D ring=decreased MC activity |
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Term
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Definition
Blocks 1st step in steroid biosynthesis (Cholesterol to Pregnenolone)
Blocks all steroid production
Used in Cushings
Chemical Adrenectomy
ACTH rises |
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Term
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Definition
Blocks last step of Cortisol syn and syn of mineralcorticoids
Used to test competency of adrenal axis (ACTH rises) |
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Term
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Definition
Induced by glucocorticoids
Blcoks lipooxygenase and Cox
will not cross react with NSAID hypersensitivity |
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