Term
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Definition
| Uncontrolled growth and spread of abnormal cells; difficult to tx b/c drugs cannot differentiate between normal and abnormal cells and thus kill both kinds |
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Term
|
Definition
Rescue therapy; tx (chemotherapy) given over a short period immediately followed by an antidote drug to spare normal cells |
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Term
|
Definition
Antimetabolites, Alkylating agents, Hormones, and Unclassified |
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Term
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Definition
Mimics/blocks a reaction that synthesizes a necessary nutrient; CA cell utilize agents faster than normal cells and are killed more quickly than normal cells
S.E.: bone marrow depression, hepatotoxicity, immunosuppression, anorexia, N&V, oral/anal ulcers, fever, rash, hair loss |
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Term
Fluorouracil (5-FU, Efudex, Adrucil) |
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Definition
Antimetabolite; legend drug- gloves should be worn to prevent application to areas not intended to use; skin irritant |
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Term
|
Definition
Antimetabolite; Legend drug |
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Term
|
Definition
Antimetabolite; Legend drug, utilizes Leucovorin as an antidote |
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Term
Cytarabine (Ara-C, Cytosar) |
|
Definition
Antimetabolite; Legend drug |
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|
Term
Thioguanine (6-TG, 6-Thioguanine) |
|
Definition
Antimetabolite; Legend drug |
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Term
|
Definition
Antimetabolite; Legend drug |
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Term
|
Definition
Antimetabolite; Legend drug |
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Term
|
Definition
Antimetabolite; Legend drug |
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Term
|
Definition
Antimetabolite; Legend drug |
|
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Term
|
Definition
tx Leukemia, testicular, ovarian, and bladder CAs. |
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Term
Alkylating Agents: Mechanisms of Action |
|
Definition
| Binds to DNA and prefet relocation; utilized to a great extent in CA cells; caution should be used during reconstitution b/c agnets can cause severe itching and burning upon contact; technician should wash throughly w/ soap and water immediately and seek medical attention in case of accidental contact w/ cytotoxic drugs; cytotoxic drugs must be prepared in a vertical hood to protect technician |
|
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Term
Alkylating Agents: Side Effects |
|
Definition
| NV&D, testicular atrophy, impotence, bone marrow suppression, hepatotoxicity, nephrotoxicity, rash, loss of taste and hearing, seizures, metal cloudiness, depression |
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Term
|
Definition
Alkylating agent; Legend drug |
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Term
|
Definition
Alkylating agent; Legend drug |
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Term
|
Definition
Alkylating agent; Legend drug |
|
|
Term
Mechlorethamine (Nitrogen Mustard) |
|
Definition
Alkylating agent; Legend drug |
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Term
|
Definition
Alkylating agent; Legend drug |
|
|
Term
Cyclophophamide (Cytoxan) |
|
Definition
Alkylating agent; Legend drug |
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Term
|
Definition
Alkylating agent; Legend drug |
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Term
|
Definition
Alkylating agent; Legend drug |
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Term
|
Definition
Alkylating agent; Legend drug |
|
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Term
|
Definition
Alkylating agent; Legend drug |
|
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Term
|
Definition
Alkylating agent; Legend drug; produces less N&V |
|
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Term
|
Definition
Uses: tx hormone dependant CA (e.g. breast cancer); both natural and synthetic hormones are used
S.E.: NV&D, hot flashes, insomnia |
|
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Term
|
Definition
Hormone; bloks effect of estrogen in target tissues (e.g. breast)
S.E.: Hot flashes |
|
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Term
|
Definition
Hormone; Legend drug; approved for use in advances (metastatic) breast CA; also being evaluated for prevention of prostate CA under brand name Acapodene |
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Term
|
Definition
Hormone; Legend drug; used to tx breast CA in postemnopausal women w/ disease progression following anti-estrogen therapy |
|
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Term
Leuprolide Acetate (Lupron) |
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Definition
|
|
Term
Medrozyprogesterone Acetate (Depo-Porvera) |
|
Definition
|
|
Term
Megestrol Acetate (Megace) |
|
Definition
|
|
Term
|
Definition
|
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Term
|
Definition
|
|
Term
Testosterone (Depo-testosterone) |
|
Definition
Hormone; Schedule III Legend drug |
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Term
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
|
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Term
|
Definition
|
|
Term
Unclassified Drug Categories |
|
Definition
Vinca Alkaloids, Asparaginase (Elspar), and Antibiotics |
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Term
|
Definition
Vinca Alkaloid; Legend drug |
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Term
|
Definition
Vinca Alkaloid; Legend drug |
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Term
|
Definition
Vinca Alkaloid; Legend drug |
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Term
|
Definition
Arrests mitotic division at the metaphase of cell division
S.E.: Bone marrow suppression, N&V, hair loss |
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Term
|
Definition
Blocks asparagine dependent protein synthesis in tumor cells
S.E.: hypersensitivity, bone marrow suppresion, bleeding, depression, N&V |
|
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Term
|
Definition
Inhibits nucleic acid synthesis |
|
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Term
|
Definition
Asparaginase: Antibiotic
Legend drug
S.E.: pulmonary fibrosis, fever, chills, N&V |
|
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Term
|
Definition
Asparaginase: Antibiotic
Legend drug
S.E.: myelosuppression, cardiotoxicity, N&V
|
|
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Term
|
Definition
Asparaginase: Antibiotic
Legend drug
S.E.: bone marrow toxicity, N&V |
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Term
|
Definition
Asparaginase: Antibiotic
Legend drug |
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Term
|
Definition
Asparaginase: Antibiotic
Legend drug |
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Term
|
Definition
Asparaginase: Antibiotic
Legend drug |
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Term
|
Definition
Asparaginase: Antibiotic
Legend drug |
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Term
|
Definition
Asparaginase: Antibiotic
Legend drug |
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