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Cancer Biology BIO346 Ch. 11
Chapter 11
38
Biology
Undergraduate 3
05/21/2012

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Term
biopsy
Definition
process of removing piece of tissue for microscopic examination that is the only way in which a definitive diagnosis can be made.
Term
colonoscopy
Definition
uses a sort of fiber-optic tube that is long enough to visualize the entire length of the colon.
Term
PSA test
Definition
measures how much prostate-specific antigen is present in the bloodstream-prostate cancer indicator.
Term
false negative
Definition
a person with cancer obtains a negative test result
Term
overdiagnosis
Definition
detection of cancers that not otherwise be hazardous.
Term
computed tomography scan (CT scan)
Definition
technique used to detect cancer that uses an X-ray scanner moving around the body taking multiple pictures that are assembled in a series of detailed cross-sectional images.
Term
ultrasound imaging
Definition
uses high-frequency sound waves and their echoes to produce a picture of internal body structures.
Term
carcinoma in situ
Definition
a cancer of epithelial region that is still in its preinvasive stage
Term
tumor grading
Definition
cancer of same type are assigned different numerical grades based on the extent of the cellular and tissue disruptions seen with a microscope.
Term
radiation therapy
Definition
uses high-energy X-rays or other ionizing radiation to kill cancer cells.
Term
brachytherapy
Definition
minimizes cell damage of normal tissues by using a radiation source that can be inserted directly within or close to a tumor-radioactive pellets.
Term
chemotherapy
Definition
use of drugs that kill cancer cells to interfere with the ability of cancer cells to proliferate
Term
analog
Definition
chemical derivatives of molecules of drugs that can substitute for the natural molecule
Term
purine
Definition
double ring compounds in DNA-adenine and quanine.
Term
platinating agent
Definition
anticancer drug.DNA-crosslinking agents that contain platinum.
Term
hormone therapy
Definition
for cancers that are in hormone-dependent tissues.
Term
androgen receptor
Definition
receptor proteins located in prostate epithelial cells that bind incoming androgens and transmit the signal that stimulates cell division.
Term
tamoxifen
Definition
molecule that exhibits some similarities to estrogen in chemical structure.
Term
glucocorticoid
Definition
steroid family produced by the adrenal cortex. can inhibit lymphocyte proliferation.
Term
multidrug resistance transport protein
Definition
plasma membrane proteins that actively pump drugs out of the cells.
Term
combination chemotherapy
Definition
use multiple drugs that differ in their mechanisms of action in order to take care of different aspects of a cancer.
Term
stem cell transplantation
Definition
bone marrow transplantation replenishes a person's hematopoietic stem cells.
Term
immmunotherapy
Definition
expoloit the ability of the immune system to recognize cancer cells
Term
cytokine
Definition
proteins produced by the body to stimulate immune responses against infectious agents
Term
B lymphocyte
Definition
class of immune cells that produce antibodies.
Term
cytotoxic T lymphocyte
Definition
bind to surface cells exhibiting foreign antigens and Kill the targeted cells by causing them to burst.
Term
dendritic cell
Definition
take up antigens, chop them into pieces and present the resulting fragment on their cell surface in a way that activates an immune response.
Term
molecular targeting
Definition
drugs designed to target proteins that are critical to the cancerous state
Term
ErbB2 receptor
Definition
produced byt the ERBB2 gene. cell surface growth factor receptor often found amplified in breast and ovarian cnacers.
Term
Gleevec
Definition
small molecule that binds to and inhibits the abnormal tyrosine kinase produced by the BCR-ABL oncogene present in chronic myelogenous leukemias.
Term
anti-angiogenic therapy
Definition
inhibition of angiogenesis as a treatment for cancer
Term
gene therapy
Definition
process of replacing defective genes with normal versions
Term
preclinical testing
Definition
drug undergoes animal testing to demonstrate that the treatment is safe and effective.
Term
informed consent
Definition
indicates a patients understanding the conditions of voluntary consent for participation in clinical trials.
Term
double blind
Definition
neither doctor nor patients know who is receiving treatment and who is receiving a placebo.
Term
placebo effect
Definition
any beneficial effect on a patient's condition that may be caused by a person's expectations concerning a drug rather than by the drug itself.
Term
complementary treatment
Definition
used along with standard medical care
Term
laetrile
Definition
natural substance from apricot pits that apparently was the cure for cancer.
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