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isocitrate dehydrogenase: activate with ADP and NAD+
a-ketoglutarate dehydrogenase: activate with ADP and NAD+/ inhibit also with succinyl CoA |
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| oxaloacetate + acetyl CoA product and enzyme and accessory molecules |
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| citrate. citrate synthase. H2O and SH-CoA |
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| citrate -> aconitate -> isocitrate enzyme |
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| isocitrate -> a-ketoglutarate enzyme and cofactors |
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| isocitrate dehydrogenase. NAD+ to NADH. Loss of CO2 |
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| a-ketoglutarate -> succinyl CoA enzyme and cofactors |
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| a-ketoglutarate dehydrogenase. NAD+ to NADH. With SH-CoA, loss of CO2 |
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| succinyl CoA -> succinate enzyme and cofactors |
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| succinyl-CoA synthetase. GDP to GTP. Loss of SH-CoA |
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| succinate -> fumarate enzyme and cofactors |
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| succinate dehydrogenase. FAD to FADH2. Loss of CO2 |
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| fumarate -> malate enzyme and cofactors |
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| malate -> oxaloacetate enzyme and cofactors |
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| malate dehydrogenase. NAD+ to NADH |
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| yield of CAC per acetyl CoA |
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