•Physiological
–Occurs in development, wound healing, reproductive cycle
–Well organized control of vascular growth
•Minimal changes in permeability, proteolysis, inflammation
•Multiple growth factor regulation
•Pathological
–Increasingly important for several disease states.
–Results in abnormal vasculature
•Torturous architecture, increased permeability, increased inflammatory and/or thrombogenic potential.
•Often due to differential gene regulation of growth factors and other angiogenesis associated genes.
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