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Staphylococcus
36
Microbiology
Graduate
02/12/2012

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Term
Gram Positive Cocci
Definition
Staphylococcus
Streptococcus
Enterococcus
Term
Staphylococcus
(General Characteristics)
Definition
Gram positive
cocci in irregular clusters
facultative anaerobe
catalase positive
grows well in limited media
Term
Catalase Positive
Definition
S. aureus-makes superoxide dismutase
Term
Staphylococcal Species (3)
Definition
S. aureus
S. epidermidis
S. saprophyticus
Term
S. aureus
Definition
Coagulase positive
Grows in high salt
causes numerous skin lesions
food poisoning (gastroenteritis)
Term
S. aureus
(Epidemiology)
Definition
Break in skin defense
Ingestion
carried in the NARES 30% population
Term
S. aureus
(Virulence Factors)
Definition
Hyaluronidase
Coagulase (prothrombin activator)
Protein A
Protease
Super antigens
Toxins
Term
S. aureus
(Toxins)
Definition
Exfoliative toxin
Toxic Shock Syndrom toxin (TSST)
Enterotoxins
Hemolysin (alpha toxin)
Leukocidin
Term
Hyaluronidase
Definition
breaks down hyaluronc acid (on surface of eukaryotic cells allowing it to spread through tissue)
Term
Coagulase
Definition
Prothrombin activator-makes itself a clot and avoids the immune system
Term
Protease
Definition
Tissue destruction
Term
Superantigens
Definition
non-specific stimulation of the immune response. 40-60% of lymphocytes are activated and all the damage that comes with it
Term
Exfoliative toxin
Definition
outer layer of skin falls off
Term
Toxic Shock Syndrome Toxin
Definition
Term
Enterotoxin
Definition
(6)-gastroenteritis-inflammation of the gastrointestinal tract
Term
Hemolysin
Definition
Alpha toxin-lyses blood cells (lymphocytes)
Term
Leukocidin
Definition
lyses leukocytes
Term
S. aureus
(Pathogenesis of skin infection)
Definition
evasion of immune system --> spread within the tissue --> potential systemic spread of toxin --> hyperactivation of the immune system
Term
S. aureus
(Pathogenesis of Ingestion)
Definition
Stimulation of neural centers--> induces vomiting
Term
S. aureus
(Clinical symptoms of skin infections)
Definition
Purulent Lesions
Peeling Skin
Systemic Shock
Term
S. aureus
(Clinical symptoms of food poisoning)
Definition
Vomiting- 2-4 hours after ingestion
Term
S. aureus
(Diseases)
Definition
Skin infection (furuncle (boil), Carbuncle
Impetigo
Soft tissue infection
Osteomyelitis
Pneumonia
TSS
Enterocolitis
Term
Impetigo
Definition
bulbous watery infection
Ecthyma-deep impetigo-pus involvement with follicles
Term
Paronychia
Definition
Infected nail beds-use systemic antibiotics
Term
Furuncle
Definition
boil-huge zit
Term
Carbuncle
Definition
consolidation of multiple furuncles
Term
Cellulitis
Definition
non-specific reddening
Term
Scalded Skin Syndrome
Definition
infants-toxin through umbilical cord
Term
Osteomyelitis
Definition
gets into bone marrow which is resistant to high blood flow
Term
Enterocolitis
Definition
eating contaminated food with enterotoxins
Term
Toxic Shock Symtoms
Definition
diarrhea, disorientation, fainting, high fever, kidney or liver problems, muscle pain, nausea and vomiting, peeling skin, shock (severely low blood pressure which affects body's functioning), sore throat, **sunburn-like rash on skin* (after one or two days)
Term
S. aureus
(treatment of skin infection)
Definition
antibiotic therapy!
Term
S. aureus
(treatment of ingestion)
Definition
TIME!
Term
S. epidermidis
Definition
normal human flora
generally non-pathogenic
may contaminate specimens/implants-forms biofilm
Term
S. saprophyticus
Definition
normal non-pathogenic environmental organism
10-20% of UTI's in young women
Coagulase NEGATIVE
Term
Coagulase Negative
Definition
S. epidermidis
S. saprophyticus
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