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Bugs and antibiotics
MMG exam 1
61
Health Care
Graduate
02/24/2009

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Term
Staphylococcus aureus
Definition
Gram +, catalase-positive, pathogen
Term
Staphylococcus epidermidis
Definition
Gram +, catalase-positive, normal flora
Term
Streptococcus pyogenes
Definition
Gram +, catalase-negative, causes rheumatic fever & pharyngitis
Term
Streptococcus pneumoniae
Definition
Gram +, catalase-negative, causes pneumonia
Term
Enterococcus faecalis
Definition
Gram +, catalase-negative, normal GI flora
Term
Neisseria gonorrheae
Definition
Gram -, oxidase-positive, causes gonorrhea
Term
Baccilus anthracis
Definition
Gram +, aerobic, spore forming rod. Causes anthrax
Term
Clostridium tetani
Definition
Gram +, anaerobic, spore forming rod. Causes tetanus
Term
Clostridium botulinum
Definition
Gram +, anaerobic, spore forming rod, produces botulism toxin
Term
Listeria monocytogenes
Definition
Gram +, non-spore forming. Normal flora.
Term
Corynebacterium diptheriae
Definition
Gram +, non-spore forming rod. Causes diptheria. Pleiomorphic.
Term
Pseudomonas aeruginosa
Definition
Gram - rod, non-fermenting (aerobic), oxidase-positive. Ubiquitous.
Term
Legionella pneumophila
Definition
Gram -, aerobic rod. Causes Legionaire's disease
Term
Bordetella pertusis
Definition
Gram -, aerobic, causes whuppin' cough
Term
Fransicella tularensis
Definition
Gram -, aerobic, causes tularemia, a zoonotic infection usually from rabbits. Engineered for antibiotic resistance by Russians during Cold War
Term
Brucella abortis
Definition
Gram -, aerobic, zoonotic infeections
Term
E. coli
Definition
Gram -, facultative anaerobe, glucose fermenter, oxidase-negative.
Term
Y. pestis
Definition
Gram -, facultative anaerobe, oxidase-negative, glucose fermenting. Causes the plague.
Term
Salmonella enteritidis
Definition
Gram -, facultatively anaerobic, oxidase-negative, ferments glucose
Term
Shigella
Definition
Gram -, facultative anaerobe, oxidase-negative, ferments glucose
Term
Vibrio cholerae
Definition
Gram -, facultative anaerobe. Causes cholera
Term
Haemophilus influenzae
Definition
Gram -, often pleiomorphic. Causes many pediatric infections
Term
Haemophilus aegyptius
Definition
Gream -, often pleiomorphic, causes conjuctivitis.
From genera: Pasteurellaceae
Term
Campylobacter jejuni
Definition
Gram -, aerobic (or microaerophilic), causes gastroenteritis
Term
Helicobacter pyloroi
Definition
Gram -, aerobic or microaerophilic, causes gastric ulcers
Term
Treponema pallidum
Definition
Gram -, helical bacteria (is a spirochete). Causes syphilis.
Term
Borrelia burgdorferi
Definition
Gram -, spirochete, causes Lyme disease
Term
Leptospiraceae
Definition
Gram -, zoonotic infections
Term
Bacteroides fragilis
Definition
Gram -, ANAEROBIC. Normal GI flora.

Can treat with Metronadizole (due to being anaerobic)
Term
Prevotella melaninogenica
Definition
Gram -, ANAEROBIC, normal GI flora.

Can treat with metronadizole (since it's anaerobic)
Term
Fusobacterium
Definition
Gram -, anaerobic, normal oropharyngeal flora
Term
Ricketsiaceae
Definition
Gram -, obligate intracellular pathogen, zoonotic with arthropod vectors
Term
Chlamydiaceae
Definition
Gram -, obligate intracellular pathogen
Term
Mycoplasma pneumoniae
Definition
No peptidoglycan cell wall! Causes pneumonia.
Term
Mycobacterium tuberculosis
Definition
Acid fast rods, causes TB
Term
Mycobacterium leprae
Definition
Acid fast rods, causes leprosy
Term
Nocardia asteroides
Definition
irregular, Gram +, aerobic, partially acid-fast
Term
Ehrlichia sp.
Definition
Gram -, obligate intracellular pathogen
Term
Name two B-lactams
Definition
B-Lactams = penicillin, cephalosporin
Term
What drugs inhibit cell wall synthesis?
Definition
B-lactams, vancomycin, bacitracin
Term
Polymyxin / Colistin
Definition
-Very toxic, polypeptide antibiotics, useful against Gram - bacteria
Term
Isoniazid
Definition
Mycobacterium cell wall inhibitor
Term
Ethambutol
Definition
Mycobacterium cell wall inhibitor
Term
Cycloserine
Definition
Mycobacterium cell wall inhibitor
Term
Streptomycin
Definition
An Aminoglycosidase. Irreversibly inhibits protein synthesis. Can be toxic to Kidneys and CN 8.
Term
Gentomycin
Definition
An Aminoglycoside. Can be toxic to CN 8 and kidneys. Irreversibly stops protein synthesis.
Term
Neomycin
Definition
An Aminoglycoside. Irreversibly inhibits protein synthesis, toxic to Kidneys and CN 8 in high doses. Bacteriocidal.
Term
Tetracyclines
Definition
Bacteriostatic only. Broad spectrum, reversibly blocks protein synthesis.
Term
Chloramphenicol
Definition
Toxic- can cause aplastic anemia. Only bacteriostatic.
Term
Erythromycin
Definition
A macrolide/lincosamide. Bacteriostatic
Term
Clindamycin
Definition
A macrolide/ Lincosamide. Bacteriostatic only.
Term
Lincomycin
Definition
A macrolide/ lincosamide. Bacteriostatic only.
Term
Linezolid
Definition
Based on a structure not found in nature- used to fight resistant organisms
Term
Ciproflaxin
Definition
Broad spectrum, a Quinolone, inhibits DNA synthesis
Term
Nalidixic acid
Definition
Narrow spectrum, a Quinolone, blocks DNA synthesis
Term
Rifampcin
Definition
Blocks RNA polymerase
Term
Metronidazole
Definition
Good against ANAEROBIC bacteria
Term
Trimethoprim
Definition
Blocks folate production, non-toxic
Term
Sulfonamides
Definition
Blocks folate production, non-toxic
Term
List some Live Vaccines
Definition
Polio, Measeles, Mumps, Rubella, Chicken-pox, typhoid, yellow fever, TB, measels, adenovirus
Term
List some ANAEROBIC bacteria
Definition
Anaerobes:
-Bacteroides fragilis
-Prevotella melaninogenica
-Fusobacterium
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