Term
| Nipple discharge is often associated with what pathologies? |
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Definition
| large duct papilloma/papillary carcinoma |
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Term
| For mammary duct ectasia, in addition to duct dilatation, what else do we find? |
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Definition
| We find periductal inflammation with numerous histiocytes |
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Term
| What is characteristic about the lesions in lymphocytic mastopathy? |
|
Definition
| the lesions are so hard it may be difficult to do a needle biopsy; collagenized stroma surrounds atrophic ducts and lobules |
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Term
| How do you classify sclerosing adenosis? |
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Definition
| Proliferative breast disease w/o atypia |
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Term
| In sclerosing adenosis, what happens to the acini? |
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Definition
| They become distorted as there is fibrous stroma surrounding them. |
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|
Term
| What cells are prominent in sclerosing adenosis? |
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Definition
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Term
| IN some of the lumens in sclerosing adenosis, what might we find? |
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Definition
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Term
| If we are presented a picture of a irregular central mass with long projections affected associated benign ductal structures, what would be our diagnosis? |
|
Definition
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Term
| What makes something Atypical Lobular Hyperplasia and not Lobular Carcinoma In Situ? |
|
Definition
| the cells do not fill or distend more than 50% of the acini within a lobule |
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Term
| What percentage of lobular carcinomas in situ are bilateral? What marker is typically absent? |
|
Definition
| 20-40%/ E-cadherin marker typically not present |
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Term
| What is typically overexpressed in Paget's disease of the breast? |
|
Definition
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|
Term
| How are Paget cells typically described? |
|
Definition
| large, anaplastic, and hyperchromatic often lying within the epidermis |
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Term
| In invasive lobular carcinoma, what does the histology typically reveal? |
|
Definition
| You see single rows of infiltrative cells (Indian lines) sometimes forming rings around benign ducts |
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Term
| In invasive lobular carcinoma, what do the small tumor cells often contain? |
|
Definition
| intracytoplasmic mucin vacuoles |
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|
Term
| In medullary carcinoma, what is the texture like? |
|
Definition
| it has a soft, fleshy consistency due to lack of desmoplasia |
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Term
| In comedo type DCIS, what are the ducts filled? |
|
Definition
| With punctate areas of necrosis (comedone) surrounded by periductal fibrosis |
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|
Term
| In which form of breast cancer do we find solid, synctial sheets of large, pleomorphic cells with increased mitotic activity and a lymphocytic infiltrate? |
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Definition
| medullary carcinoma with lymphoid infiltration |
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Term
| In which carcinoma do we find soft, large, gelatinous tumors and, upon histology, islands of tumor cells with copious mucin? |
|
Definition
| colloid (mucinous) carcinoma |
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Term
| In tubular carcinoma, what is unusual about the tubules? |
|
Definition
| There are angulated borders and no myoepithelial cells |
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|
Term
| In inflammatory carcinoma, why is there breast swelling and thickening? |
|
Definition
| there is lymphatic obstruction, leading to erythematous edema of the skin (peau d' orange) |
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Term
| If there are 1-3 axillary lymph nodes involved, what is the breast cancer prognosis for recovery? |
|
Definition
| 35-40% 10 year disease free survival |
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|
Term
| Which breast cancer type has the poorest prognosis? |
|
Definition
| inflammatory carcinoma- 3 year survival of only 3 to 10% |
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|
Term
| In stage I breast cancer, what are the parameters? |
|
Definition
| invasive carcinoma 2 cm or less w/o metastases |
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|
Term
| What are the parameters for Stage III breast cancer? |
|
Definition
| Invasive carcinoma 5cm or less with 4 or more involved nodes/ >5 cm with nodes/ invasive carcinoma with 10 or more nodes/ involvement of ipsilateral mammary nodes/ inflammatory carcinoma |
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Term
| What gives the phyllodes tumor its leaf-life consistency? |
|
Definition
| due to nodules of proliferating stroma covered by epithelium |
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|
Term
| How does angiosarcoma typically arise and when does it? |
|
Definition
| It's an associated complication of radiation therapy, often arising 5-10 years after treatment |
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|
Term
| In gynecomastia, what two things are proliferaing? |
|
Definition
| ductal epithelium and intralobular stroma |
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