Term
| Non-Neoplastic - Acquired |
|
Definition
Acute mastitis/Abscess
Silicone Implants
Fibrocystic Change/Disease
--Sclerosing Adenosis
--Large Duct Papilloma
Traumatic Fat Necrosis |
|
|
Term
| Silicone Implants and Assoc Changes |
|
Definition
pseudo-capsule - resembles pearly white joint capsule
Foreign Body Type Granulomatous response |
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|
Term
| Fibrocystic Changes/Disease |
|
Definition
Most Common Disorder of Breast
Women 25-45
Increased Estrogen or Decreased Progesterone
Lumpy Breast
Midcycle tenderness
Blue Dome Cysts
Apocrine metaplastic cells in Papillary configuration
Nonproliferative: No increased risk of breast cancer
Proliferative: Epithelial hyperplasia or Sclerosing adenosis, slight increased risk of cancer |
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|
Term
|
Definition
Fibrocystic Change
Proliferation of small duct and Myoepithelial cells with Fibrosis
Microcalcifications
Firm, Rubbery, painless, well-circumscribed
Actin + myoepithelial cells
Radial Scar
Compressed Tubular Glands
Dense Fibrous Stroma |
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|
Term
|
Definition
Fibrocystic Change
Estrogen Sensitive
Apical Ductal Hyperplasia-> increased risk of cancer
Intraductal papilloma-> Bloody Nipple discharge
Women <50yo |
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|
Term
|
Definition
Trauma
Lactation, Pregnancy, Sports Activity
Lipid Laden macrophages
Calcifications
Puckering of Skin
Foamy Macrophages or Giant cells |
|
|
Term
|
Definition
Most Common Benign Tumor
Women 20-35
Fibroadenomatosis
-- Post Renal Transplant
-- EBV in immunosuppressed
Circumscribed
Freely Mobile
Stromal w/ epithelial component
Stroma-> Benign
Estrogen Responsive |
|
|
Term
|
Definition
Derived for Stromal Cells
45yo, Latin American Hispanics
Like Fibroadenomas but recur
can be malignant
Benign: Resemble FA w/ cell stroma
Borderline: Mitotic figures. Recur
Malignant: Rare, stromal>ductal growth, Hypercellular stroma with mitoses. |
|
|
Term
|
Definition
Male breast enlargement
increased estrogen/androgen ratio
alcohol, cirrhosis, drugs, Kleinfelter's, decreased estrogen metabolisium, |
|
|
Term
| Atypical Ductal Hyperplasia |
|
Definition
Ductal structures with epithelial proliferation and cellular atypia
Lumens not fully occluded/not sharply defined
Increased risk of carcinoma
Multilayering of cells
Enlarged Nuclei |
|
|
Term
| Atypical Lobular Hyperplasia |
|
Definition
Lobular proliferation
Monomorphic
Focal preservation of luminal spaces |
|
|
Term
Breast Cancer
Predisposing Factors |
|
Definition
Age
(+)FH
Hx of Cancer in one breast
Early menarche/Late menopause
Obesity
Nulliparity
HRT
1st pregnancy after 30yo
High Fat Diet
Proliferative Fibrocyctic Disease
Endometrial Cancer, Ionizing radiation, Smoking
High Breast Density |
|
|
Term
|
Definition
|
|
Term
Ductal Carcinoma in situ
(DCIS) |
|
Definition
Nonpalpable
microcalcifications
Do Not involve Stroma
4x more common than LCIS
1/3 eventually evade |
|
|
Term
Lobular Carcinoma in situ
(LCIS) |
|
Definition
Cluster of Neoplastic cells
Bilateral
Nonpalpable
not identified by mammography
Usually E/P receptor positive |
|
|
Term
|
Definition
DCIS variant
Tumors fill ducts, necrosis results in cheese like consistency
40%-> invasive
Her2 amplification
p53 positive
ER/PR negative |
|
|
Term
| Paget's Disease of Breast |
|
Definition
Eczematoid lesion of nipple/areola
Underlying Ductal Carcinoma
Large Cells, Clear Cytoplasm
PAS stain |
|
|
Term
|
Definition
Most Common Type
Penetrative
Calcifications
Tubule Formations
Nuclear pleomorphism and mitoses
Invades Stroma
Tumor cells arranged in Sheets |
|
|
Term
| Invasive Lobular Carcinoma |
|
Definition
Neoplastic cells arranged in lines
Mets-> CSF, BM, GIT, Serosal Surfaces, ovary, uterus
Signet Ring Cells |
|
|
Term
|
Definition
Enlarged Edematous Breasts
Peau d'orange
Lymphatic occlusion
Tumor plugs lymphatics-> lymphedema
Poor Prognosis, Aggressive |
|
|
Term
|
Definition
Extracelluar mucus surrounding clusters of tumor cells
Elderly Women
Slow Growth |
|
|
Term
|
Definition
Terminal Ductules
Well differentiatied
Good Prognosis
50yo |
|
|
Term
|
Definition
usually younger women
Poor Prognosis
Anastomosing vascular channels lined by atypical cells
Hyperchromatic malignant endothelial cells
Stain + for Factor VIII antigen & CD34 |
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