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Breast Pathology
08/31/07 Hanau Lecture
9
Medical
Graduate
08/31/2007

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Cards

Term
Granulomatous Mastitis
Definition

primary granulomatous inflammation of breast lobules (not assoc. with any other organ involvement)

Term
Duct Ectasia
Definition

dilation of large ducts containing fatty detritus and surrounded by fibrosis and chronic inflammation.

  • postmenopausal
  • subareolar
  • nipple d/c
  • lesion palpable
  • may cause skin retraction

 

Term
fat necrosis of the breast
Definition
hx of trauma 1-2 weeks prior often in elderly with pendulous breasts early lesions hemorrhagic then becomes brown with central liq oily fluid fibrosis --> firm SQ mass, may cause dimpling of skin
Term
Mondor's Dx
Definition
breast infarct thrombophlebitis of breast and adjacent thoraco-abdominal wall
 
gross: firm, nodular, cord-like induration under skin micro: thrombosis and phlebitis; sudden in onset
Term
fibroadenoma
Definition
GROSS well-circumscribed easily movable no necrosis
 
MICRO stroma: usually loose CT epithelial: round glands or are elongated, distorted by growth of stromal cells rarely become malignant
Term
cystosarcoma phyllodes
Definition
  • similar to fibroadenoma, but less well delineated
  • stroma is more cellular
  • can be benign or malignant
[image]
Term
Intraductal papilloma
Definition
most common cause of nipple d/c (serous/serosanguinous/sanguinous)
 
location: subareolar, from large CD
gross: pedunculated, greyish tan, soft easily friable, within dilated duct
micro: complex papillary configurations wtih fibrovascular core with 2 layers of cells (outer epithelial and myoepithelial)
Term
fibrocystic changes (aka disease)
Definition
presence of cysts within breast in excess of "normal" tenderness common bilateral 24-45 y.o. women
 
gross: somewhat poorly delineated and mod firm, containing several to numerous cysts.
 
micro:
* cysts; lined by flat cells and sometimes by columnar cells
* apocrine metaplasia: cells very eosinophilic
* fibrosis
Term
ductal carcinoma in situ (DCIS) - list 4 types aka in situ ductal carcinoma intraductal carcinoma
Definition
types:
  • comedocarcinoma
  • in-situ papillary carcinoma
  • solid in-situ ductal carcinoma
  • micropapillary in-situ ductal carcinoma
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