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Brain Stem Pathologies
Unit 4 Material
62
Other
Graduate
03/17/2011

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Term
Since the brainstem contains a compact arrangement of diverse structures, what will normally happen with a single lesion?
Definition
It will damage several structures simultaneously.
Term
What 3 things can a unilateral lesion of the brain stem cause?
Definition
1. Loss of function to 1 or more cranial nerves on the ipsilateral side of the body
2. Contralateral hemiplegia
3. Contralateral hemisensory loss
Term
Why can a unilateral lesion of the brain stem cause contralateral hemiplegia?
Definition
Because long descending motor pathways innervate contralateral extremities
Term
Why can a unilateral lesion of the brain stem cause contralateral hemisensory loss?
Definition
Because long ascending sensory pathways carry sensory information from contralateral extremities
Term
What is another term for Lateral Medullary Syndrome?
Definition
Wallenburg's Syndrome
Term
Has been attributed to occlusion of either the PICA (posterior inferior cerebellar artery) because this artery supplies the dorsolateral portion of the medulla, or the vertebral artery - from which the PICA arises- this artery is actually the more frequently occluded
Definition
Lateral Medullary Syndrome (Wallenburg's Syndrome)
Term
What artery supplies the dorsolateral portion of the medulla?
Definition
PICA
Term
From which artery does the PICA arise?
Definition
Vertebral
Term
Between the PICA and the vertebral artery, which one is more frequently occluded?
Definition
Vertebral artery
Term
What structures are usually involved in Wallenburg's Syndrome?
Definition
1. Spinal Trigeminal Tract & Nucleus
2. Anterolateral System Pathway
3. Nucleus Ambiguus
4. Descending Sympathetic Fibers - from hypothalamus to spinal cord - descending near the spinothalamic tract
5. Inferior Cerebellar Peduncle (part)
Term
Name 5 deficits seen with Wallenburg's Syndrome
Definition
1. Loss of pain and temp over ipsi. side of face and contra side of body
2. Hoarseness and difficulty swallowing
3. Ipsilateral Horner's Syndrome
4. Vertigo
5. Disturbances of equilibrium
Term
Unusually results from interruption of descending autonomic pathways that course in the dorsolateral horn system (from hypothalamus). May also occur secondary to disruption of these fibers in the spinal cord and with lesions involving either preganglionic or postganglionic sympathetic fibers of the superior cervical ganglion.
Definition
Horner's Syndrome
Term
Name 5 characterizations of Horner's Syndrome.
Definition
1. Miosis
2. Partial Ptosis
3. Enophthalmos
4. Anhidrosis
5. Vasodilation
Term
What does miosis mean?
Definition
Constricted pupil (because dilator muscle is paralyzed)
Term
Why will you see partial ptosis with Horner's Syndrome?
Definition
Because smooth muscle fibers in the levator palpebrae superioris muscle are denervated
Term
What does Enophthalmos mean?
Definition
Eye appears to be sunken in socket
Term
Absence of sweating on affected side of face.
Definition
Anhidrosis
Term
Causes redness of face on affected side
Definition
Vasodilation during Horner's Syndrome
Term
Generally caused by acoustic neuroma
Definition
Cerebellopontine Angle Syndrome
Term
A slow growing tumor arising from Schwann cells in sheath of CN VIII
Definition
Acoustic Neuroma
Term
Dizziness
Definition
Vertigo
Term
Ringing in the ear
Definition
Tinnitus
Term
Name 4 initial symptoms of 8th nerve damage seen in cerebellopontine angle syndrome
Definition
Progressive Deafness
Tinnitus
Vertigo
Spontaneous Horizontal Nystagmus
Term
As the tumor in Cerebellopontine Angle syndrome grows, what might you see?
Definition
Ipsilateral Facial Paralysis
Cerebellar Ataxia on side of lesion
Facial Pain
Term
With Cerebellopontine Angle syndrome, why might you see ipsilateral facial paralysis as the tumor grows?
Definition
Due to proximity to the CN VII
Term
With Cerebellopontine Angle syndrome, why might you see cerebellar ataxia on the side of lesion?
Definition
Compression of cerebellar peduncles
Term
With Cerebellopontine Angle syndrome, why might you see facial pain?
Definition
Pressure of V root if tumor is large
Term
What may cause Weber's Syndrome?
Definition
Occlusion of posterior cerebral arteries
Term
Weber's syndrome causes lesion involving what 2 things?
Definition
cerebral peduncle
occulomotor nerve
Term
Name 6 symptoms present with Weber's Syndrome.
Definition
1. Contra hemiplegia b/c of involvement of corticospinal pathways
2. External strabismus of ipsi eye - unopposed action of CN VI
3. Ipsi ptosis
4. Ipsi pupillary dilation
5. Ipsi loss of adduction of eye beyond midline
6. ipsi loss of upward and downward movment of eye
Term
Lesions of the pontine/mesencephalic tegmentum involving significant amounts of reticular activating system
Definition
Coma
Term
Caused by an occlusion of the basilar artery - bilateral innervation of the ventral pons. Lesions of the corticobular and corticospinal tracts.
Definition
Locked-in Syndrome
Term
Name 3 symptoms of a person with Locked-In Syndrome
Definition
1. Total Paralysis
2. Unable to speak
3. Fully awake - may be able to slightly move eyes
Term
What does the PICA supply?
Definition
posterior tips of the rostral medulla
Term
Vascular supply is paramedian branches of vertebral and anterior spinal artery
Definition
Medial Medulla
Term
Name 3 structures involved in the medial medulla.
Definition
1. Pyramidal Tract
2. Medial Lemniscus
3. Hypoglossal Nucleus and Exiting Nerve
Term
Name 3 symptoms that can be seen with a lesion to the medial medulla.
Definition
1. Contra arm and leg weakness
2. Contra decreased position and vibration sense
3. Ipsi tongue weakness
Term
Major blood supply to the pons
Definition
Basilar artery
Term
With this syndrome, the cortex is fine, the person has no voluntary movement, limited/no face movment, and can breathe on their own.
Definition
Locked-In Syndrome
Term
What blood supply goes to the midbrain
Definition
Posterior Cerebral Arteries
Term
What all cranial nerves could possibly be involved with cerebellopontine angle syndrome.
Definition
VIII
VII
V
Term
This tract controls motor to the face.
Definition
Corticobulbar
Term
This tract is going to have voluntary movement.
Definition
Corticospinal Tracts
Term
Name 2 tracts that run through the pons
Definition
Corticobulbar
Cortiospinal
Term
What is another term for the inferior cerebellar peduncle?
Definition
Restiform Body
Term
Are there cranial nerves present in the brain stem?
Definition
Yes
Term
Are there cranial nerves present in the spinal cord?
Definition
no
Term
If you have a spinal cord injury in the cervical region - T1-2, lateral medulla or any interruption up to the thalamus will result in what syndrome?
Definition
Horner's
Term
Injury to what region may cause ataxia (walking with a wide BOS)
Definition
Inferior Cerebellar Peduncle
Term
Where can you find occulomotor fibers and the red nucleus?
Definition
Midbrain
Term
In what 2 syndromes can you find Ptosis?
Definition
Horners and Webers
Term
What artery innervatees the medial lower medulla?
Definition
Anterior Spinal Artery
Term
Does Webers effect parasympathetic or sympathetic?
Definition
Parasympathetic
Term
Does Horners effect parasympathetic or sympathetic?
Definition
Sympathetic
Term
Name 2 components that if injured can cause a coma.
Definition
RAS - Reticular Activating System - controls level of arousal
Cortex & Basal Ganglia
Term
What artery supplies the olive in the medulla?
Definition
Vertebral artery
Term
If you have a bilateral lesion to the thalamus, can this result in a coma?
Definition
Yes
Term
If you have a unilateral lesion to the thalamus can this result in a coma?
Definition
No
Term
If you have a unilateral hemisphere dysfunction - a massive head injury to the cortex unilaterally, can this result in a coma?
Definition
NO
Term
If you have a bilateral hemisphere dysfunction - a massive head injury to the cortex bilaterally, can this result in a coma?
Definition
Yes
Term
Barbituates depress the cortex, if you overdose on barbituates, can this result in a coma?
Definition
Yes
Term
Can you have a coma from an upper midbrain, reticular formation or pontine dysfunction?
Definition
Yes
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