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Pharmacokinetics
8
Medical
Professional
02/27/2008
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Term
Vd
 Definition
amount of drug in body/concentration in body
Term
Clearance
 Definition

rate of elimination/plasma drug concentration

 

Vd x Ke (elimination constant) 
Term
halflife
 Definition
0.7 x Vd/CL
Term
Loading Dose
 Definition

Cp(target) x Vd/B
Term
Maintenance dose
 Definition
Cp(or MD/DI) x CL/B
Term
Therapeutic Ratio
 Definition
Max safe dose/Min effective dose
Term
Maximum dosing interval
 Definition
1.44 x t1/2 x ln(TR)
Term
Steady state time
 Definition
4 t1/2
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