Term
| What drug is a cofactor for the activation of antithrombin → ↓ thrombin and ↓ Xa? |
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Definition
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Term
| What anticoagulation therapy can be used during pregnacy because it doesn cross placenta? |
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Definition
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Term
| What drug is associated with thrombocytopenia? How is this reversed? |
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Definition
Heparin
HIT
(Heparin Induced Thrombocytopenia)
Protamine Sulfate
positively charged molecule that binds negatively charged heparin |
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Term
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Definition
Heparin binds to platelet factor IV → antibody production that binds to and activates platelets →
clearance of platelets →
thrombocytopenic, hypercoagulable state |
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Term
| What anticoagulant drugs act more on Xa? |
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Definition
Low-Molecular-Weight Heparins
Enoxaparin
(all end in -parin) |
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Term
| What drugs can be used as an alternative to heparin for patients with HIT? |
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Definition
Hirudin Derivatives
Lepirudin
Bivalirudin
(all end in -irudin like Hirudin) |
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Term
What drug interferes with normal syntesis and γ-carboxylation of vitamin K-dependent clotting factors?
What are the Vitamin K-dependent clotting factors? |
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Definition
Warfarin
Vitamin K dependent Factors:
Clotting factors:
II, VII, IX, X
Anti-Clotting factors:
Protein C and S |
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Term
What side effects can occur from Warfarin toxicity?
How is Warfarin Toxicity Reversed? |
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Definition
Side Effects:
Bleeding, Teratogenic, Skin/Tissue Necrosis, Drug-Drug interactions
Reversal of warfarin overdose with:
Vitamin K and Fresh Frozen Plasma |
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Term
What lab test should be followed in patients taking Heparin?
What lab test should be followed in patients taking Warfarin? |
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Definition
Heparin: Follow PTT
Warfarin: Follow PT/INR |
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Term
| What drugs directly or indirectly aid conversion of plasminogen → plasmin? What does this do? |
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Definition
Thrombolytics
Streptokinase
Urokinase
tPA
APSAC
Plasmin Cleaves Thrombin and Fibrin Clots
[image] |
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Term
What Lab values do the Thrombolytics affect?
Streptokinase
Urokinase
tPA
APSAC |
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Definition
↑ PT
↑ PTT
No Change in Platelet Count |
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Term
| What drug Acetylates and irreversibly inhibits COX-1 and COX-2 to prevent conversion of arachidonic acid to thromboxane A2? |
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Definition
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Term
| What drug inhibits platelet aggregation by irreversibly blocking ADP receptors and inhibits fibrinogen binding by preventing glycoprotein IIb/IIa expression? |
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Definition
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Term
What drugs are used in the treatment of Acute coronary syndrome and coronary stenting?
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Definition
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Term
| What drugs inhibit phosphodiesterase III and ↑ cAMP in platelets → platelet aggregation inhibition? |
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Definition
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Term
| What drugs are used for intermittent claudication, coronary vasodilation, angina prophylaxis, and the prevention of strokes or TIAs? |
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Definition
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Term
| What drugs used in prevention of stroke can cause nausea, headache, facial flushing, hypotension, and abdominal pain? |
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Definition
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Term
| What drug is a monoclonal antibody that binds Gp IIb/IIa on activated platelets to prevent aggregation? |
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Definition
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Term
| What drug is used for percutaneous transluminal coronary angioplasty and acute coronary syndromes? |
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Definition
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