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Board Prep Biochem
Board Prep Biochem
15
Biochemistry
Graduate
04/03/2012

Additional Biochemistry Flashcards


 

 


 

Cards

Term
What amino acids are modified by the Golgi apparatus?
Definition

Serine

Threonine

Asparagine

Term
What are the mRNA stop codons?
Definition

UGA

UAA

UAG

 

U Go Away

U Are Away

U Are Gone

Term
What substance inhibits RNA polymerase II in eukaryotes causing liver damage?
Definition

α-Amanitin


(Found in death cap mushrooms)

Term
What Antibiotics bind at the 30S and the 50S subunits of RNA?
Definition

buy AT 30, CCELL at 50.

 

30s Subunit:

Aminoglycosides

Tetracyclines

 

50s Subunit:

Chloramphenicol

Clindamycin

Erythromycin

Lincomycin

Linezolid

Term

What collagen is most frequently affected in Ehlers -Danlos syndrome?

 

What are the common symptoms?

Definition

Ehlers-Danlos Syndrome

 

Faulty collagen synthesis of Type III collagen

 

Causing:

Hyperextensible Skin

Tenedency to bleed

Hypermobile joints

 

Associated with:

joint dislocation

Berry aneurysms

Organ Rupture

Term
What is Alport Syndrome?
Definition

Alport Syndrome

 

Gene defect resulting in abnormal type IV collagen 


Most Common form is X-linked recessive

 

Characterized by:

progressive nephritis and deafness

Ocular disturbances

Term

What are the Rate Limiting Steps for the following?

 

Glycolysis

Gluconeogenesis

TCA cycle

Glycogen synthesis

Glycogenolysis

Definition

Glycolysis:

Phosphofructokinase-1 (PFK-1)

 

Gluconeogenesis:

Fructose-1,6-bisphosphatase

 

TCA cycle:

Isocitrate dehydrogenase

 

Glycogen synthesis:

Glycogen synthase

 

Glycogenolysis:

Glycogen phosphorylase

Term

What are the rate limiting steps for the following pathways?

 

HMP shunt

De novo pyrimidine synthesis

De novo purine synthesis

Urea Cycle

Definition

HMP shunt

Glucose-6-phosphate dehydrogenase (G6PD)

 

De novo pyrimidine synthesis:

Carbamoyl phosphate synthetase II

 

De novo purine synthesis:

Glutamine-PRPP amidotransferase

 

Urea Cycle:

Carbamoyl phosphate synthetase I

Term

What is the Rate limiting step for the following pathways?

 

Fatty acid synthesis

Fatty acid oxidation

Ketogenesis

Cholesterol synthesis

Definition

Fatty acid synthesis:

Acetyl-CoaA carboxylase

 

Fatty acid oxidation:

Carnitine acyltransferase I

 

Ketogenesis:

HMG-CoA synthase

 

Cholesterol synthesis:

HMG-CoA reductase

Term

What glycogen Storage disease matches:

 

Glycogen phosphorylase deficiency

Painful muscle cramps, myoglobinuria with strenuous exercise

Definition

Type V

McArdle's Disease

 

McArcle's = Muscle

Term

Which glycogen storage disease matches:

 

Glucose-6-phosphatase Deficiency

Lactic acidosis, hyperlipidemia, hyperuricemia

Increased glycogen in liver, Severe Fasting Hypoglycemia

Severe Hepatosplenomegaly, Enlarge Kidneys

Definition

Type I

Von Gierke's Disease

 

 

Term

Which glycogen storage disease matches the following:

 

α-1,6-glucosidase deficiency

Hepatomegaly, hypoglycemia, hyperlipidemia

 

Definition

Type III

Cori's disease

Term

Which Glycogen Storage disease matches the following:

 

α-1,4-glucosidase deficiency

Cardiomegaly (infantile)

diaphragm weakness leading to respiratory failure (adult)

 

Definition

Type II

Pompe's disease

Term

What are the 5 cofactors required for

Pyruvate Dehydrogenase?

 

 

TCA Cycle

Pyruvate  Acetyl-CoA

Definition

Pyruvate Dehydrogenase Complex cofactors:

 

Thiamine (B1)

Lipoid Acid

CoA (B5, pantothenate)

FAD (B2, riboflavin)

NAD (B3, niacin)

 

TLC For No one

 

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