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BMS 300
Exam 1
42
Physiology
Undergraduate 4
09/17/2009

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Term
Is water polar or non-polar?
Definition
Polar, allows it to form hydrogen bonds
Term
Hydrophobic means....
Definition
Water "fearing" molecules that tend to assosiate with other molecules rather than water
Term
Hydrophilic means....
Definition
Water "loving", contempt in an aques enviroment
Term
Amphipathic means...
Definition
Neutral/both ways. Hydrophilic charged phosphate head groups, fatty acid side chains.
Term
A Protein is...
Definition
A sequence of amino acids
Term
Define Prokaryotes
Definition
single celled organisms containing Ribosomes, single strand DNA, and cytoskeletal elements.
Term
Define Eukaryotes
Definition
surrounded by a biological membrane, contain numerous membrane bound organelles such as:
Mitochondria
Vessecles
Lysisomes
Nucleous
Term
What is the definition of DNA
Definition
Deoxyribose Nucleaic Acid that is found in the nucleus.
Bases are:
Adennine
Thymine
Cytosine
Guanine
Term
What is RNA and what does it do?
Definition
Single stranded Ribose sugar found throughout the cell and are usually single stranded. Their job is to code proteins using codons. Bases:
Adenine
Uracil
Cytosine
Guanine
Term
What is the Helicase's role in DNA replication?
Definition
To "unzip" the DNA molecule by seperating hydrogen bonds so it can later be copied or transcribed.
Term
What follows the Helicase in DNA replication and what is it's function?
Definition
Polymerase: To match each base with it's compliment (T:A---C:G)
only moves from the 3' end to 5' end.
Term
What is Transcription?
Definition
Making an mRNA copy of the DNA. Transcription starts with the promoter bonding to the TATA box, and then an RNA is brought in to match base pairs of DNA with the compliment RNA.
Term
What are Introns and Exons?
Definition
Introns are part of the RNA that is removed, and Exons are spliced together to form the mRNA
Term
What is the process of Translation?
Definition
making a protein by using mRNA as a code for amino acids.
Term
WHere does Translation occur?
Definition
All translation begins in the cytoplasm and occurs at the ribosomes
Term
What is Glycosylation?
Definition
the process of adding sugars to proteins. This begins in the RER Lumen, then continues to the Golgi Apparatus.
Term
Once a protein enters the Golgi Apparatus through Glycosolation, what 3 things can happen to it?
Definition
1. Secreted Proteins: travel to cell membrane via vessicle, fuses with the membrane, and the protein then exits to extracellular space.
2. Lysosomal Proteins: Travel via vessicle to the lysosome.
3. Transmembrane Proteins: Travel to cell membrane via vessicle and fuse to the membrane, where it remains, sugars pointed out.
Term
What is a tissue?
Definition
A collection of similar cells that perform a similar function.
Term
What are Epithelial Tissues?
Definition
Closely spaced cells connected by cellular junctions. POLARIZED.
Term
What are gap junctions?
Definition
communicating junctions composed of 6 transmembrane proteins (connexions that together make a connexon.) They allow molecules less than 1000 molecular weight through (NO PROTEINS)
Term
What are Tight Junctions?
Definition
Don't allow anything from the Lumen to find its way between the cells.
Term
What are Desmesomes and what do they do?
Definition
Anchor cells together and are composed of transmembrane proteins (cadherins) reaching out to other cells.
Term
What are Hemidesmisomes and what do they do?
Definition
Attach Epitheliac cells to the Basil Lamina and are composed of transmembrane proteins (integrins) that reach out to the basil lamina.
Term
What are Tight Junctions?
Definition
Don't allow anything from the Lumen to find its way between the cells.
Term
What is Connective Tissue?
Definition
Extracellular matrix surrounding spaced out cells (a network of proteins linked together)
Collagen
Ellastin
Glycosaminoglycans
Term
What is an example of a "True Organ"?
Definition
Skin, because it has several different tissue types.
Term
What is the Epidermis?
Definition
Outter layers of skin, made up of epithelial tissue
Term
What is the Dermis?
Definition
Deeper layer, made up of connective tissue. Contain blood vessels which nourish the Epidermal layers.
Term
What are the 4 layers of the Epidermis?
Definition
1. Stratum Basale: bottom layer, source of replicant cells.
2. Stratum Spinosum: Next layer, VIT D.
3. Stratum Grandulosum: Granules containing "glycolipid" which keeps the skin waterproof.
4. Stratum Corneum: dead skin cells containing Keratin.
Term
What does the Endocrine System use as chemical messengers?
Definition
Hormones
Term
What are some of the main functions of the Endocrine System?
Definition
1. Homeostasis-internal enviroment
2. Energy Utilization-insulation, glucagon, and cortisol
3.Growth and Development-Growth hormone, Thyroid hormone.
Reproduction-Estrogen, Testosterone, and Progesterone.
Term
What are the 3 pathways of the Endocrine System?
Definition
1.Endocrine: Hormones released from the cell and travels through the bloodstream.
2.Paracrine: Hormones are picked up by neighboring cells.
3.Autocrine: Target cell is the same as the releasing cell.
Term
What are the 3 main types of proteins?
Definition
Protein/Peptide Hormones
Steroid Proteins
Modified Amino Acids
Term
Define Steroid Hormones
Definition
Chelesterol derivatives that are lipid soluble meaning they can easily diffuse the cell membrane making their receptors intracellular.
Term
What is the Anitomical breakdown of the Pituitary Gland
Definition
Posterior Pituitary: Extension of the Hypothalimus.
Anterior Pituitary: Seperated from the Hypothalimus by a bloodstream.
Term
What are the functions of the Posterior Pituitary gland.
Definition
Secretes 2 hormones:Oxytocin (muscle contraction at birth)
Anti-Diuretic Hormone-Helps you retain water
Term
What are the functions of the Anterior Pituitary Gland?
Definition
True Gland: Controlled by hormones from the Hypothalamus.
Also releases 6 hormones of its own:
Growth Hormone/ACTH/Thyroid Stimulating Hormone/LH/FSH/Prolactin
Term
What is the Growth Hormone, and what does it do?
Definition
Nuerons in the Hypothalimus cause it to release from the Anterior Pituitary Gland into the blood where it goes to its receptors on the liver and fat. Once the liver is stimulated by a GH it secretes IGF-1 which causes bone growth.
Term
Where does the Adrenocorticotropic Hormone (ACTH) originate and what is it's function in the Endocrine System?
Definition
Nerves fire at the level of the Hypothalamus which activate ACTH in the Anterior Pituitary gland, they stimulate cells in the adrenal cortex to secrete cortisol.
Term
What does Cortisol do?
Definition
Helps maintain blood glucose levels
Term
What is the Thyroid Stimulating Hormone?
Definition
Releasing factors from the Hypothalamus release TSH from the Pituitary and from there it travels to it's target, the Thyroid gland. Once there Thyroid hormones are secreted which increase metabolic rate and body temperature. Also promotes growth in children.
Term
What does the Parathyroid Hormone do?
Definition
Takes calcium out of the bone and releases it into the bloodstream. This is only activated if calcium levels are too low.
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