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Blood & Circulation
AANT318
119
Physiology
Undergraduate 4
02/20/2013

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Cards

Term
fibrinogen
Definition
What is needed for clots?
Term
hemocrit
Definition
the proportion of the packed red blood cells to the total volume of the blood sample
Term

short life span 

90-120 days

Definition
What is a life span of an erythrocyte? (RBC)
Term
red blood cells
Definition
What cells transport oxygen from the lungs throughout the body and lack a nuclei?
Term
hemoglobin
Definition
What is a red, iron-containing pigment that binds oxygen in the lungs and releases some of its as the blood goes through the different organs?
Term
erythropoiesis
Definition
What is the production of red blood cells?
Term
bone marrow, myeloid tissue
Definition
Where does the production of red blood cells occur?
Term

erythropoietin

kidneys

Definition
What is the hormone that stimulates the production of red blood cells? Where is secreted from?
Term

transportion

thermoregulation

protection

Definition
What are the three main functions of RBCs?
Term
lymph nodes, tonsils, spleen, thympus and lymphoid tissue
Definition
Where are leukocytes produced?
Term

granulocytes:

basophil, neutrophil, eosinophil

Definition
Which leukocytes are granulocytes?
Term

agranulocytes

monocytes, macrophages, lymphocyte (T cell and B cell)

Definition
Which leukocytes are agranulocytes?
Term

recognize foreign matter

CSF and interleukins

MHC Major histocompatibility complex

Definition
What are the functions of leukocytes?
Term
Major histocompatibility complex
Definition
What is the process where you need to match for proteins for tissue donations?
Term
neutrophils
Definition
Which leukocytes is most numerous?
Term
neutrophils
Definition

Functions: respond most quickly to bacterial invasion

defensin

phagocytic cells, which can leave the blood and enter the connective tissue

 

Which leukocyte is this? 

Term
eosinophils
Definition

Functions: release histaminase

effective against parasitic worms

 

Which leukocyte is this? 

Term
basophils
Definition

Functions: inflammatory and allergic reactions

rarest type of WBC

contain the anticoagluant: heparin

 

Which leukocyte is this? 

Term
monocytes
Definition

Functions: transform into macrophages

can enter the connective tissues

phagocytic cells 

Term

lymphocytes

B cells

Definition
Which leukocyte is involved with humoral immunity?
Term

lymphocytes

T cells

Definition
Which leukocytes is involved with cell-mediated immunity?
Term

platelets

thrombocytes

Definition
What are fragment of cells which are also called megakaryocytes in the bone marrow?
Term
form the body of blood clots
Definition
What is the function of platelets?
Term
platelet plug
Definition
When the endothelium is damaged, platelets stick to the exposed connective tissue and release molecules that attract other platelets causing many plateletes to aggregate and form?
Term

platelet plug 

coagulation

Definition
What is the two step process that involves in hemostasis?
Term
postive feedback mechanism
Definition
What type of mechanism is a platelet plug?
Term
ADP, serotonin, TXA2
Definition
What does bound platelets releases?
Term
actin and myosin
Definition
What tightens up the seal of a platelet plug?
Term

prostacyclin (PGI2)

nitric oxide (NO)

Definition
What is found in undamaged vessels to inhibit a clot in forming?
Term
thrombus
Definition
In coagulation, what is need to form a clot?
Term
fibrinogen into fibrin
Definition
In coagulation, what does thrombin splits into?
Term
enzyma factor XIIIa
Definition
What enzyme helps strengthen fibrin?
Term

tissue factor pathway inhibitor (TFPI)

thrombomodulin

anti-thrombin III

Definition
What are some anticoagulant mechanisms?
Term
agglutinate
Definition
What is the term where blood clumps together?
Term
artery
Definition
What blood vessels carry blood away from the heart?
Term
veins
Definition
What blood vessels carry blood to the heart?
Term
atria
Definition
Which two chambers of the heart receive blood from the veins?
Term
ventricles
Definition
Which heart chamber pump blood into the arteries?
Term

AV valve

(atrioventricular valve)

 

tricuspid valve

Definition
Which AV valve separate the right atrium from the right ventricle?
Term

bicuspid, mitral 

valve

Definition
Which AV valve separates the left atrium from the left ventricle?
Term
semilunar valves
Definition
This valve is located at the opening where blood leaves each ventricle to enter the atrial system.
Term
pulmonic valve
Definition
This semilunar valve at the exit of the right ventricle is the ______.
Term
aortic valve
Definition
This semilunar valve at the exit of the left ventricle is called _____.
Term
left atrium
Definition
Which chamber is blood returned to?
Term
left ventricle
Definition
Which chamber pumps blood into the largest artery of the body, aorta?
Term
systemic circulation
Definition
What kind of circulatiion: from the heart (left ventricle) to all the body system and back to the heart (right atrium)?
Term
pulmonary circulation
Definition
Which circulation: from the heart (right ventricle) to the lungs and back to the heart (left atrium)?
Term
cardiac cycle
Definition
What is the repeating pattern of contraction and relaxation of the heart's chambers?
Term
systole
Definition
What is the phase of contraction?
Term
diastole
Definition
What is the phase of relaxation?
Term
end-diastolic volume
Definition
What is the contraction of the atria adds to the total amount of blood that will be in the ventricles at the end of their diastole?
Term
stroke volume
Definition
When the ventricle contracts, the amount of the blood they eject is called ______ .
Term
two-thirds
Definition
What amount of the end-diastolic volume is the stroke volume of a resting person?
Term
isovolumetric contraction
Definition
As the ventricles begin contracting at systole, the pressure within them rises sharply, becoming greater than the pressure in the atria; this snaps the AV valve shuts. What is the phase called?
Term
Ejection
Definition
When the pressure in the ventricles becomes greater than the pressure in the arteries, the semilunar valves open. The pressure within the left ventricle starts to fall as blood leaves it, but the pressure in the aorta will rise about 120 mmHg as a result of systole. What is this phase called?
Term
isovolumetric relaxation
Definition
As the pressure in the ventricles falls below the pressure in the arteries, the pressure difference causes the semilunar valves to snap shut, preventing backflow. When the AV valves and semilunar valves are closed, so that no blood can flow into the ventricle. This is the beginning of diastole. What is this phase called?
Term
rapid filling
Definition
When the pressure in the ventricle falls below the pressure in the atria, the AV valves open and a phase of _____ ______ of the ventricle occurs. This is still diastole.
Term
atrial contraction
Definition
___ ____ empties the final amount of blood into the ventricles to complete the end-diastolic volume, just before the next ventricular contraction (systole).
Term
first heart sound (lub)
Definition
What sound is produced by closing of the AV valves at the beginning of systole?
Term
second heart sound
Definition
What sound is produced by the closing of semilunar valves at the beginning of diastole?
Term
murmurs
Definition
What is an abnormal heart sounds usually produced by defective valves or other structual defects that result in blood flowing in an abnormal way in the heart?
Term
prolapse
Definition
What is the protruding up into the left atrium because of the risinig pressure in the left ventricle during systole?
Term
sinoatrial (SA) node
Definition
What is the normal pacemaker region of the heart which is located in the right atrium near the opening of the superior vena cana?
Term

AV node

AV bundle (bundle of His) 

 

Definition
What is the specialized mass of conductin tissue located in the right atrium near the junction of the interventricular septum. It transmit the impulse into the bundle of His.
Term
Purkinje fibers
Definition
Motor tracts conduction tissue in the ventricles of the heart that carry impulses from the bundle of His to the myocardium of the ventricles.
Term
pacemaker potential
Definition
automatic depolarization occurs during diastole
Term
Ca2+-stimulated Ca2+ release
Definition
The Ca2+ that enters the myocardial cell through the plasma membrane during the plateau phase stimulates contraction. It does this by stimulating the opening of the Ca2+ release channels in the SR, which allows the Ca2+ from the SR to diffuse into the cytoplasm and bind to troponin.
Term
long plateau phase
Definition
What is the long action potential or long refractory period (contraction time)?
Term
bradycardia
Definition
What is a cardic rate slow than 60 beats per minute?
Term
tachycardia
Definition
What is a resting cardiac rate faster than 100 beats per minute?
Term
flutter
Definition
What occurs when the conractions are coordinated but extremely rapid (200-300 beats per minute)?
Term
fibrillation
Definition
In what, different myocardial cells produce action potential and contract at different times, so that a coordinated pumping action is impossble?
Term
atrial fibrillation
Definition
What happens when action potentials are produced extremely rapidly and the atria cannot effectively pump?
Term
cardiac output
Definition
What measures the pumping ability of the ventricles and is equal to the stroke volume multiplied by the cardiac rate?
Term
arteries
Definition
Which blood vessel does not have a valve?
Term
artery
Definition
Which blood vessel is thicker due to vasoconstriction and vasodialation?
Term
tunica externa
Definition
What is the connective tissue of blood vessels?
Term
tunica media
Definition
What is the smooth muscle of blood vessel?
Term
tunica interna
Definition
What is includes the lining endothelium, a simple sqamous epithelium?
Term
elastic arteries
Definition
Which blood vessel has the highest blood pressure?
Term
end-diastolic volume
Definition
What is the amount of blood in ventricles at the end of diastolic, immediately prior to contraction?
Term
total peripheral resistance
Definition
What is the frictional resistance to blood flow in arteries (primarily arterioles) that provides an impedance to the ejection of blood from the ventricles?
Term
contractility
Definition

What is the strength of the ventricle's contraction? 

 

Term
arterioles
Definition
Which blood vessel is the major resistance?
Term
Frank-Starling Law of the Heart
Definition
What is the direct relationship between end-diastolic volume, myocardial stretch, and the strength of myocardial contraction?
Term
venous return
Definition
The end-diastolic volume depends on the amount of blood during diastole flowing in veins back to the heart. What is this called?
Term
skeletal muscle pump
Definition
What is the contractions of skeletal muscles give the blood a push by squeezing veins located between the muscle?
Term
breathing pump
Definition
The higher pressure in the abdominal cavity helps blood move up the inferior vena cava back to the right atrium of the heart.
Term
baroreceptors
Definition
What are the sensors for arterial blood pressure?
Term
aortic arch and carotid sinuses
Definition
Where are baroreceptors located?
Term
total blood volume
Definition
What affects the venous return to the hart, and thereby the end-diastolic volume, stroke volume, and cardiac output?
Term
kidneys' production of urine
Definition
How is total blood volume regulated?
Term
filtration pressure
Definition
When fluid is filtered out of the capillary walls due to the capillary blood pressure, what is it called?
Term
colloid osmotic pressure
Definition
What is the outward movement of fluid that is opposed?
Term
lymphatic system
Definition
What transports excess interstitial fluid back into the blood, transports absorbed fat from the small intestine into the blood, and help provide immunological defense against disease-causing agents?
Term
lymphatic capillaries
Definition
What is the smallest vessels of the lymphatic system?
Term
  1. high arterial blood pressure
  2. venous obstruction
  3. leakage of plasma proteins into the interstitial fluid
  4. Decreased plasma protein concentration
  5. Obstruction of the lymphatic drainage
Definition
What are the three probable causes of edema?
Term
ADH and Aldosterone
Definition
What adjust the renal regulation of blood volume?
Term
osmolarity
Definition
What influenced the secretion of ADH?
Term

1. dehydration, which reduces the amount of water

2. eating salt (NaCl) 

Definition
How is plasma osmolarity raised?
Term

juxtaglomerular apparatus

renin

Definition
What is the group of cells in the kidney that stimulated to secrete an enzyme? What is this enzyme called?
Term
angiotensin I
Definition
Renin converts a protein in the blood called angiotensinogen into a short polypeptide called _____. This polypeptide is inactive until circulated into the blood.
Term
angiotensin-converting enzyme (ACE)
Definition
What enzyme changes angiotensin I to angiotensin II?
Term
angiotensin II
Definition
What stimulates the adrenal cortex to secrete aldosterone and stimulates vasocontriction of aterioles?
Term
renin-angiotensin-aldosterone system
Definition
What is the relationship between renin, angiotensin and aldosterone known as?
Term
arterial pressure
Definition
What drives blood flow?
Term
perpherial resistance
Definition
What hinders blood flow?
Term
blood pressure
Definition
What is proportional between cardiac output and peripheral resistance?
Term
coronary arterioles
Definition
What constrict in response to norepinephrine and dilate in response to epinephrine?
Term
intrinsic metabolic vasodilation
Definition
As the heart's metabolism increases, local chemical changes in the myocardium act on the vascular smooth muscle to cause vasodilation. This reduces the resistance to flow and thereby increase the bloof flow through the heart.
Term
intrinsic myogenic regulation
Definition

The blood flow to the brain is maintained between relatively constant despite changes in the arterial blood pressure. A rise in arterial blood pressure acts on the smooth muscle cells in the arterial walls to cause constriction of the cerebral arteries. 

 

The blood flow relatively constant, but distribution is variable. 

Term
autoregulation
Definition
What is the ability of an organ to self-regulate its blood flow?
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