Term
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Definition
| Successfully giving people a blood component they lack |
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Term
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Definition
| The process where the body is protected from disease and foreign invaders |
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Term
Which type of hemolysis is the following:
Cell membrane is destroyed by COMPLEMENT (Not by ABY) |
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Definition
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Term
Which type of hemolysis is the following:
ABY is attached to RBC membrane
Complex is removed by the SPLEEN |
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Definition
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Term
Which type of Immunity is the following:
Involves the production of ABYs by B lymphs that are converted to plasma cells |
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Definition
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Term
| Once coated with ABY, cell is either destroyed by what 3 things? |
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Definition
phagocytosis
complement
removed by the spleen |
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Term
Which type of immunity is the following:
Involves the direct interaction of T lymphs with foreign cells |
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Definition
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Term
| 2 Examples of Cellular Immunity are |
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Definition
Delayed hypersensitivity
Transplant Immunology |
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Term
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Definition
| Lyses ABY coated cells and serves to mediate opsonization to prepare for phagocytosis by neutrophils and macrophages |
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Term
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Definition
| Substances capable of inducing a specific immune response |
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Term
True or False:
AGNs that stick out tend to be More Antigenic |
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Definition
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Term
| Epitope is the portion of the antigen where.... |
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Definition
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Term
| Antigens can be acquired through (4) |
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Definition
Pregnancy
Inhalation
Injection
Ingestion |
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Term
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Definition
| Protein synthesized by plasma cells |
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Term
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Definition
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Term
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Definition
| ABY to foreign substances |
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Term
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Definition
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Term
| 2 Classes of ABYs found in BB |
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Definition
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Term
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Definition
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Term
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Definition
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Term
True or False:
IgG is naturally occurring |
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Definition
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Term
True or False:
IgM is naturally occurring |
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Definition
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Term
|
Definition
| The ability of an ABY to react with a Specific AGN |
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Term
| First Stage of Antigen-Antibody Reaction is |
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Definition
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Term
| Second Stage of Antigen-Antibody Reaction is |
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Definition
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Term
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Definition
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Term
|
Definition
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Term
True or False:
Sensitization stage is a Random Pairing determined largely by Chance |
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Definition
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Term
True or False:
For the Sensitization Stage an ABY is attached to AGN on the RBC membrane but a Visible Reaction is NOT observed |
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Definition
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Term
| An ____ in _____ will Increase the Probability of Collision |
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Definition
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Term
| What 3 things may influence the probability for collision in the Sensitization stage? |
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Definition
ABY concentration
AGN Receptor accessibility
AGN Receptor concentration |
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Term
| 4 Environmental Factors that influence the Sensitization stage |
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Definition
Incubation time
Temperature
pH
Ionic Strength |
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Term
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Definition
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Term
| IgG reacts at what temperature? |
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Definition
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Term
| IgM reacts at what temperature? |
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Definition
| Room Temperature or lower |
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Term
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Definition
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Term
| After sensitization the ABY-coated RBCs are necessary to develop __________ for the visualization of RBC clumping |
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Definition
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Term
| Agglutination forms when RBCs are in close proximity to promote ____ formation between the ABY and Antigenic sites on adjacent RBCs |
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Definition
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Term
| What 3 things influence the Agglutination Stage? |
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Definition
Distance between the RBCs
Optimal concentrations of ABYs and AGNs
Effect of Centrifugation |
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Term
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Definition
| The force or repulsion between RBCs in a physiologic saline solution |
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Term
| RBCs possess a net _____ charge on the cell surface in a saline suspension |
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Definition
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Term
| Cations ( ______ charge) from the saline environment are attracted to these charges on the RBCs |
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Definition
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Term
True or False:
The distance between the RBCs is proportional to the zeta potential |
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Definition
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Term
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Definition
| The larger size, pentameter shape and multivalent properties easily facilitates agglutination between RBCs that have it attached |
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Term
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Definition
| ABY is smaller and less able to span the distance between adjacent RBCs generated by the zeta potential |
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Term
True or False:
IgG may be attached but visible agglutination may not occur |
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Definition
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Term
| Maximum agglutination is observed by the concentration of AGNs and ABYs which fall within the _____ ___ _____ |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| What does centrifugation help to facilitate? |
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Definition
| the formation of a lattice network |
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Term
| ____ and ____ of centrifugation aid in the detection of agglutinated RBCs |
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Definition
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Term
| In addition to agglutination, what else may ACTIVATE COMPLEMENT |
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Definition
| an antigen-antibody reaction |
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Term
What type of response is the following:
Takes 5-7 days
More IgM
Nees more AGN to stimulate |
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Definition
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Term
What type of response is the following:
Takes 24-48 hours
Total titer is higher
Titer lasts longer
Mostly IgG
Memory B cells
Delayed hemolytic transfusion Reaction |
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Definition
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