Term
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Definition
Origin: Ant. Pit.
Structure: Protein
Regulated: Stim-GHRH
Inhib-Somatostatin
F(x): growth of bone and cartilage;increase protein synthesis in body;lipids to FA for energy;decrease use of glucose as energy source which raises glucose levels resulting in increased glycogen storage.
Excess: Symmetric gigantism in children and acromegaly in adults
Deficiency: In children causes symmetrical dwarfism.
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Term
| How does GH act on the liver? |
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Definition
| Indirectly by inducing liver to produce somatomedins(protein growth factors). |
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Term
How does malnutrition effect GH?
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Definition
| Increased levels of blood glucose or aminos, as it occurs in malnutrition, stimulates the pituitary to stimulate the secretion of GH, thereby restoring lost tissue proteins |
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Term
| Negative Feedback control of GH |
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Definition
Somatomedin production inhibit GH production by;
1)direct action on AP
2) secretion of somatostatin from hypothalamus
3)GHRH from hypo. inhibits its own secretion |
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Term
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Definition
ORIGIN: AP(acidophil cells)
STRUCTURE: Protein
REG: PRH(stim) and ESPECIALLY PIF(inhib) |
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