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specialized connective tissue consisting of free cells and a fluid intercellular matrix |
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55% of blood volume. water with dissolved proteins and inorganic salts. |
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most commonly used blood stain. RBCs pink. WBC cytoplasm blue, nuclei dark blue. |
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specialized for O2 transport. lose nucleus, ER, golgi, centrioles, most mitochondria. bag of Hb. |
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RBCs adhering to each other via concaved surfaces to form long rows |
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newly released RBCs that still contain some RNA which gives diffuse basophilia to cytoplasm |
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true cells with nucleus. arise, function, and die in connective tissues. just utilized blood as means of transport. |
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allows passage through blood vessel walls into connective tissues |
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prominent purple staining nucleus with only a small amount of pale staining cytoplasm |
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differentiate into plasma cells, manufacture and secrete antibodies |
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characterized by kidney shaped nucleus with very fine granules in the cytoplasm. differentiate into macP after exiting bloodstream. |
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lobed nuclei with granules |
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2-6 lobes. chemotactically drawn to infection. anaerobic via glycogen supply. phagocytize dead cells. major component of pus. |
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extension from lobes in some neutrophils from females contains inactivated X chromosome. |
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bi-lobed. red granules. most common in intestinal and respiratory mucosa. indicate parasites or allergic. phagocytize Ag/Ab complexes. |
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purple granules. precursor to mast cells. release histamine and other vasoactive mediators during immediate hypersensitivity or anaphylactic response. |
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biconvex disc. 2-4micrometers. formed from megakaryocytes. 3 types of granules. cytoskeletal filaments. component of intrinsic clotting mechanism. release serotonin which is a vasoconstrictor. |
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all blood cells derived from a common cell called a hemocytoblast |
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one stem cell for granulocytes and another stem cell for all other blood cells |
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occurs in bone marrow. cell size decreases. nucleus eccentrically located prior to expusion. cytoplasm becomes increasingly larger constituent of cell and changes from highly basophilic due to ribosomes to eosinophilic due to Hb |
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made by kidney. increase in response to hypozia. controls hematopoiesis |
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marrow cavities of flat bones |
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hematopoiesis in embryonic development |
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first yolk sac, then liver, then spleen, the bone marrow |
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macP of spleen, liver, BM |
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remove Hb retaining fragments and senile RBCs from circulation. break down to billirubin and iron. iron recycled as feritin or hemosiderin. bilirubin sent to liver to be excreted with bile |
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precursor cells represent 60% of BM cells. spend less time in blood (6-10 hrs). short functional lifespan (10 days in connective tissue). |
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order of granulocytopoesis |
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myloblast>>specific promylocyte>>mylocyte>>metamylocyte>>band(stab) cell>>granulocyte cell size decreases, nucleus becomes smaller and eventually forms lobes. granules appear at mylocyte stage. |
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life cycle of lymphocytes and monocytes |
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formed in bone or lymphatics. long life span. |
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live many years. can enter, leave, and re-enter blood stream many times |
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have limited life span. replaced via differentiation of uncommitted stem cells. dead ones can enter circulation, especially in pathology and form embolism. |
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