Term
| Hemochromatosis causes and result? |
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Definition
-Caused by mutated/deficient HFE which helps bring Fe into enterocytes from plasma
-The low cellular Fe causes an excess expression of DMT1 (divalent metal transporter 1) and thus high total Fe
-The excess Fe gets complexed to Ferritin and eventually to Hemosiderin which damages various tissue
-damages liver (cirrhosis), pancreas (diabetes), joints (arthritis), and skin (dermatitis and discoloration)
-"bronze diabetes"
-It is not really a problem for women because of menstruation |
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Term
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Definition
| -Protein that complexes ferric iron (Fe3+) in cells (up to 4,300 |
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Term
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Definition
-Always seems to be transported in +3 state (ferrous)
-Transported in blood by transferrin which can do 2 at a time |
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Term
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Definition
| -Name for complexed ferritin |
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Term
| What is the dietary form of Fe? How is it converted? |
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Definition
-Fe3+
-Converted with ferric reductase, or by VITAMIN C |
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Term
| What compounds limit iron absorption? |
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Definition
| -Oxalates, phosphates, phytates, tannates |
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Term
| Iron def; causes and symptoms? |
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Definition
-Can be caused by excessive bleeding, inhibited absorption (by a compound), lead poisoning (inhibits the chelation of iron onto protoporphyrin by ferrochelatase)
-Symptoms will be weakness with hypochromic, microcytic anemia
-Levels of iron, ferritin, and ALA (esp.) will depend on whether it is legitimate Fe def. or lead poisoning
-Also, with lead you will get sideroblastic cells |
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