Term
| T/F: nAChRs are found mostly postsynaptically, & lead generally to a mitigated neurotransmitter release |
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Definition
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Term
| T/F: nAChRs are found mostly presynaptically, & affect the channel via voltage-gated calcium channels & increasing intracellular calcium concentrations |
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Definition
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Term
| T/F: nAChRs are both presynaptic & postsynaptic; they depolarize the neuron & activate voltage gated calcium channels & also raise the intracellular calcium concentration |
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Definition
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Term
| T/F: nicotinic receptors in the NAc are thought to promote self-administrative behavior in animals |
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Definition
| false (nicotine receptors are not in the NAc; rather it is dopamine receptors - nicotine receptors are only in the VTA [for the reward pathway]) |
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Term
| smoke cigarette --> low or high nicotine? |
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Definition
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Term
| high nicotine --> nAChRs activated or deactivated? |
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Definition
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Term
| nAChRs activated --> VTA activity increased or decreased |
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Definition
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Term
| nAChRs activated --> increase or decrease in # of nAChRs |
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Definition
| decrease (desensitization) |
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Term
| decrease in # of nAChRs (desensitization) --> low or high nicotine? |
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Definition
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Term
| low nicotine --> increase or decrease in # of nAChRs? |
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Definition
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Term
| increase in # of nAChRs --> low or high nicotine? |
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Definition
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Term
| low nicotine --> receptors recover from ______ |
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Definition
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Term
| What would happen if glutamate reuptake transporters were inhibited/blocked? |
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Definition
| the postsynaptic receptors would desensitize to glutamate |
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Term
| inhibition of glutamic acid decarboxylase would lead to a deficit in which molecule? |
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Definition
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Term
| If blocking GAT prolongs a GABAergic IPSP, what is the main termination mechanism for GABA? |
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Definition
| reuptake (rather than enzyme degradation) |
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Term
| which step in the biosynthetic pathway for EPI is the rate-limiting step? |
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Definition
| tyrosine to L-DOPA via TH |
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Term
| AAAD is found in the synthesis of which four molecules? |
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Definition
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Term
| What type of catecholamine neurotransmitter would a neuron release if it had no VMAT or DAT? |
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Definition
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Term
| write out the whole catecholamine biosynthetic pathway |
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Definition
| tyrosine (via TH) --> L-DOPA (via AAAD) --> DA (via DHB) --> NE (via PNMT) --> EPI |
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Term
| 2 mechanisms through which termination of catecholamine response occurs |
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Definition
1. enzymatic degradation
2. reuptake |
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Term
| T/F: MDMA & amphetamine are both agonists for serotonin receptors |
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Definition
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Term
| T/F: MDMA & amphetamine both increase the amount of neurotransmitter/neuromodulator in the synapse by releasing more vesicles |
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Definition
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Term
| T/F: MDMA & amphetamine both increase the amount of neurotransmitter/neuromodulator in the synapse by blocking their respective transporters & making it work in reverse |
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Definition
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Term
| Do cocaine & amphetamine both block DAT? |
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Definition
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Term
| what is serotonin's biosynthetic pathway? |
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Definition
| tryptophan (via tryptophan hydroxylase) --> 5-HTP (via AAAD) --> 5-HT |
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Term
| serotonin is an example of a ______ |
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Definition
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Term
| what transporter packages serotonin into vesicles? |
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Definition
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Term
| When tyrosine, TH, & a catecholamine (DA, NE, or EPI) are put into a test-tube, why is L-DOPA not produced? |
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Definition
| there is a negative feedback loop that inhibits TH |
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Term
| 2 requirements for LTP to occur |
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Definition
1. postsynaptic neuron must be sufficiently depolarized
2. magnesium block of NMDARs must be removed |
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Term
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Definition
1. block NMDARs
2. chelate intracellular calcium |
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Term
| T/F: if you elicit an action potential starting in the axon hillock, that action potential can travel through the axon as well as the dendrites |
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Definition
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