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a nexus between neuron & neuron |
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the synapse as viewed by a physiologist |
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Are synapses really big or really small? |
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first man to really study synapses |
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What experiment led to the theory of "animal electricity"? |
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if you connect an iron rod from spinal cord to a muscle in the leg, the frog would kick |
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theory that all neurons are connected to each other (contiguous) kind of like a web |
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if you put silver nitrate on brain tissue, it will enter neurons & fill them to look black |
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base on his visual, Golgi thought that the reticulum theory was right |
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drew/traced cells using the same technique as Golgi; his theory: neurons are discrete entities |
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advantage of sea slugs to study synapse (specifically, neuronal plasticity) |
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from animal to animal, cells are exactly the same |
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advantage of frog neuromuscular junction (NMJ) for research |
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large synapse, easy to isolate from the frog for experimentation |
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advantage of squid giant axon for research |
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really large (500 microns) & has a huge diameter because it mediates an escape response in the squid to swim away very fast |
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assumption made when using model systems |
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the system in which you're studying something holds true across various instances |
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Otto Lowi (Loewi) 1921 experiment (1936 Nobel Prize) |
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proof that chemical neurotransmission can occur; researching how heart rate was controlled |
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Sir John Eccles vs. Sir Bernard Katz |
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Eccles: still maintained that synapses work electrical
Katz: believed in chemical |
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something that could explain correlation because it causes each of the two correlating variables |
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Controlled experiments try to eliminated ______ variables |
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need to make sure something is sufficient to cause something else to happen |
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need to prove that something is necessary to cause something else to happen |
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Neurons are about _____ microns at their maximum diameter |
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