Term
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Definition
| minimum inhibitory concentration (e.g. mg/mL), the least amount of drug that prevents visible growth of a predetermined number of organisms (usuallY 90%) |
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Term
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Definition
| good index of antibiotic exposure, and it depends directly on dose, but is influence by F and Cl |
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Term
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Definition
remember MIC is always in vitro
(generally AUC is over 24 hours) |
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Term
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Definition
| area under the inhibitor curve using actual inhibitory titers |
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Term
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Definition
| cumulative percentage of time over 24 hour period that the drug concetratione xceed the MIC at steady state conditions during the dosing interval |
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Term
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Definition
measured in hours
reflects bacterial recovery time
can be in vitro or vivo
we know this exists but we can't be specific on how long the effect will be and which patient it will happen for |
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Term
| concentration dependent killing |
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Definition
higher the conc, the greater the rate & extent of bactericidal activity
Cpk/MIC or AUC/MIC
AG, FQ, metronidazole |
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Term
| minimal concentration or time-dependent killing |
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Definition
saturation of the killing rate occurs at low mulitples of the MIC - usually 4-5x
largely dependent on the time of exposure
t >MIC
eg. beta -lactams, vanc, clinda, macrolides |
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Term
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Definition
| time dependent and bactercidal |
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Term
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Definition
typically bactericidal with concentration dependent killing
Cpk/MIC and AUC 0-24/mic |
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Term
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Definition
exhibit concentration dependent killing for gram - bacteria
(possibly time dependent for gram + bacteria)
Cpk/mic ratio is most commonly linked to clinical outcomes |
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Term
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Definition
exhibit time - dependent killing and usually bactericidal by inhibition of cell wall synthesis (therefore, the bacteria must be growing)
t>mic and possibly AUC/mic
PAE = 2-3 hours for gram +
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Term
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Definition
generally bacteriostatic, clarith and azith are bactericidal agains S. pyogenes, S. pneumo, and H. flu
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Term
erythromycin and clarithromycin
best predictor? |
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Definition
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Term
azithromycin
best predictor? |
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Definition
| best correlated with AUC0-24 hour/MIC |
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