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Birnaviridae
VM 607 Final
11
Veterinary Medicine
Professional
02/28/2012

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Term
Birnaviridae Characteristics
Definition
bi= 2 segments; rna = RNA
non-enveloped, medium sized
segmented dsRNA
incubation period
Term
Birnaviridae Entry
Definition
endocytosis
Term
Birnaviridae Replication and Release
Definition
in cytoplasm
cytolysis
Term
Birnaviridae Tropism
Definition
Pre-B lymphocytes
macrophages
Term
Birnaviridae Transmission
Definition
horizontal and vertical
Term
Infectious Bursal Disease Characteristics
Definition
Birnaviridae
type 1 serotype in US
affects chickens 3-6 weeks of age
short incubation period
Term
Infectious Bursal Disease Tropism
Definition
GI tract associated cells
lymphoid cells (especially pre-B-lymphocytes)
macrophages
Term
Infectious Bursal Disease Pathogenesis
Definition
get virus from feces
primary replication in GI tract lymphocytes and macrophages
primary viremia in bursa of pre-B cells
secondary viremia infects other tissues
Term
Infectious Bursal Disease Signs
Definition
immunosuppression: B-cell deficiency, viral bursectomy, diminished antibody responses
Term
Infectious Bursal Disease Transmission
Definition
horizontal - orofecal
possible vertical spread
Term
Infectious Bursal Disease Control
Definition
vaccinate hens
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