Underactivity in the Medial Prefrontal Cortex (responsible for judgement)

Loss or damage to brain cells in the hippocampus

Abnormal activity in the basal ganglia, especially the globus pallidus

Li3

A salt

7UP

1970

Diminishes sensitivity of neurotransmitter receptors

Delays NE

Absorbed in GI tract and not metabolized in liver

Toxicity a common problem

Monthly blood tests

SE: hand tremor, fatigue, drowsiness

Decreased fluid or food intake

Diuretic use

Fever

Nausea, dihrrhea, vomiting

water loss

kidney disease

Tegretol

Inhibis kindling

SE if dosage raised too quickly:

vomiting and nausea

ataxia

drowsiness

dizziness & clumsiness

Anticolernigic effects

Trileptal

Anticholergic effects

Many serious, but rare side effects

Depakote/Depakene

Equal to Li3 in tx. or mania

Safer than lithium

SE: Gi sx., sedation, tremors

Klonopin

Many uses including seizure disorders

Cariprazine - Vraylar

Olanzapine - Zyprexa

Vortioxetine - Trintellix

Lamictal

Side effects: Rash, GI problems, dry mouth, sore throat, runny nose, blurred vision, headache

SAPHRIS

Neuroleptic Malignant Syndrome