Abciximab

Reopro

Anti-platelet GP IIb/IIIa Receptor

•  Blocks aggregation
• IND: angioplasty, unstable angina, MI
• no surgery, trauma or bleeding within 6 wks

Alteplase

Activase

Trobolytic (tPA) 5 domains

1st generation

• plasminogen activator, enzyme
• IND: acute MI, stroke, Pulmonary embolism

2nd gen - retavase, tenecteplase

Retavase

2nd generation Thrombolitic 5 domain

Diffuse faster

2nd generation Thrombolytic

• aa substitutions
• increased specificity
• increased half life

Pegaptanib Sodium

Macugen

Pegalyated 

• IND: macular degeneration (wet/age)
• aptamer drug, binds and inactivates ex. VEGF

Peginterferon alfa 2a and 2b

Pegasys

Peg-Interon

pegylation

• hepatitis C
• once a week dosing

Pegfilgrastim

Neulasta

Pegylated

• IND: decrease neutropenia from chemotherapy
• decrease clearance rates

Pegvisomant

Somavert

Pegylated

•  acromegaly (excessive growth)

Methoxypolyethyleneglycol epoetin beta

Mircera

Pegylated EPO

• IND: anemia of chronic kidney disease
• decreased clearance rates

INSULIN

• microparcipitates, releases slowly
• no peak

INSULIN

• Rapid acting, fast

INSULIN

• Rapid onset, fast

Pegaptanib Sodium

Macugen

Aptomer

• pegylated 28 mer olgionucleotide
• inject into eye
• IND: age related macular degeneration
• binds to and inactivates extracellular VEGF

Fomivirsen Sodium

Vitravene

Antisense

• Olgionuceotide
• Inject into eye
• IND: Cytomegalovirus (SMV) retinitus in HIV
• Blocks synthesis of CMV immediate early protein IE2

Now thought to be interferon inducer

Interferon

Infergen

Consensus Sequence

• IND: treatment of adult hep C patients
• causes flu like symptoms, depression, irritability

Epoetin Alfa

Epogen

1st generation EPO drug

• cytokine, stimulates RBC production
• IND: Anemia induced by chemo & AZT therapies, chronic renal failure
• 1st biotech blockbuster,
• abused!

Darbepoetin

Aranesp

2nd generation EPO (glycosylated)

• Sialylated EPO
• IND: anemia, renal failure, chemo
• 3 fold longer half-life b/c of increase Glycosylation

Imiglucerase

Cerezyme

Lysosomal Glycosidase Enzyme

• IND: gaucher's Disease TYPE 1

Agalsidase Beta

Fabrazyme

Lysosomal Glycosidase Enzyme

• Fabry Disease

Laronidase

Aldurazyme

Lysosomal Glycosidase Enzyme

• Hurler, Scheie & Hurler-Scheie forms of mucopolysaccharidosis I

Galsulfase

Nagalzyme

Lysosomal Glycosidase Enzyme

• Maroteaux-Lamy Syndrome or MPS-VI mucopolysaccharidosis

Etanercept

Enbrel

Pseudoantibody

• fusion protein of TNF-alfa receptor + IgG1Fc
• IND: symp of ankylosing spondylitis; plaque psoriasis; psoriatic arthritis; rheumatoid arthritis
• Contraindication: serious infection or sepsis

Alefacept

Amevive

Pseudoantibody

CD-2 receptor

Abatacept

Orencia

Pseudoantibody

T-cell Antigen 4 site

Gemtuzamab Ozogamicin

Mylortag

Immunotoxin

•  CD-33 humanized monoantibody + calicheamin
• IND: acute myloid leukemia
• Calicheamicin far to toxic to be used in therapy alone

Denileukin Diftitox

Ontak

Fusion Toxin

• A/B Diptheria Toxin to IL-2 fragment
• IND: CD-25+ T-Cell lymphoma
• orphan drug, very expensive

Cell Therapy

• Stem cell concentrator
• IND: bone marrow transplants

Cell Therapy

•  increase Condrocytes
• IND: Repair traumatic knee damage

Graftskin

Apligraf

Cell Therapy

• Skin construct
• IND: venous leg ulcers
• Diabetes patients

Somatropin

Genotropin, Nutropin, Humatrope

Growth Hormones

Ecoli Derived Growth Hormone

Somatrem

Protropin

Growth Hormone

Methionyl Growth Hormone

Somatropin

Saizen, Serostim, Zorbative

Growth Hormone

Mammalian