Term
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Definition
-pathway where metabolism of carbs, amino acids, and fatty acids can converge
-aerobic metabolism
-precursors are converted to CO2
-conenzymes are reduced (NAD+ to NADH)
-provide potential E for ATP production
-occurs in mitochondria |
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Term
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Definition
-no net production/consumption of intermediates
-not a closed cycle |
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Term
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Definition
-conversion of pyruvate to acetyl CoA
-pyruvate is transported into mitochondria prior to rxn
-enzyme-pyruvate dehydrogenase complex (PDH complex)-5 enzyme subunits
-Acetyl CoA can also by used from breakdown of fatty acids and can be used for fatty acid synthesis |
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Term
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Definition
-inhibited by high ATP
-activated by high pyruvate |
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Term
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Definition
-arsenic poisoning
-inhibits PDH complex
-pyruvate accumulates and causes cell death |
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Term
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Definition
-synthesis of citrate from acetyl CoA and OAA
-enzyme-citrate synthase |
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Term
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Definition
-isomerization of citrate to isocitrate
-enzyme-aconitase |
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Term
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Definition
-oxidative decarboxylation of isocitrate to alpha-ketoglutarate
-enzyme-isocitrate dehydrogenase
-rate limiting step of TCA cycle
-yields 1 NADH, 1 CO2 |
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Term
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Definition
-oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA
-enzyme-alpha-ketoglutarate dehydrogenase complex
-yields 1 NADH, 1 CO2 |
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Term
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Definition
-cleavage of succinyl CoA to succinate
-enzyme-succinate thiokinase
-yields 1 GTP |
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Term
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Definition
-oxidation of succinate to fumarate
-enzyme-succinate dehydrogenase
-embedded in inner mitochondriaal membrane
-yields 1 FADH2 |
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Term
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Definition
-hydration of fumarate to malate
-enzyme-fumarase
-malate is also formed by purine synthesis, catabolism of Phe and Try, urea cycle |
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Term
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Definition
-oxidation of malate to OAA
-enzyme-malate dehydrogenase
-regenerates OAA to continue cycle
-yields 1 NADH |
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Term
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Definition
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Definition
-activated by OAA
-inhibited by citrate |
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Term
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Definition
-inhibited by ATP and NADH
-activated by ADP and Ca |
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Term
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Definition
-inhibited by NADH and succinyl CoA
-activated by Ca |
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Term
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Definition
-glycolysis-2 ATP,2 NADH
-prelim TCA- 2 NADH
-TCA- 6 NADH, 2 FADH2, 2 GTP |
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