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-diffusible molecules that specify differentiation of a cell type at a specific location |
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-cell fate determined by location along the gradient/morphogen concentration at a specific location -cells may migrate to a lower or higher concentration of a specific morphogen |
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-active form of vitamin A -posteriorizes the body -high concentrations in the embryo induce posterior structures to form |
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-family of proteins -help establish dorsal/ventral patterns |
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-secreted glycoproteins -important in establishment of cell polarity, proliferation, apoptosis, cell fate, migration |
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-important for early development -early patterning, cell migration, differentiation |
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-notochord -high conc. at floor of neural tube -induces formation of interneurons and motor neurons |
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-many different altered phenotypes arise -holoprosencephaly, digit malformations |
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-investigative cancer treatments -suppresses Shh signaling |
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-often specifies fate of precursor cells, maintenance of stem cell populations |
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-growth factor signaling -regulate cell proliferation, apoptosis, migration -growth of new blood vessels and axonal processes |
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8 weeks (end of embryonic period) |
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-head nearly as large as body -limbs present -cardiovascular system functional -all systems present |
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-blood cell formation begins -sex readily detectable |
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-prominant cerebellum -face looks human |
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-fetal position -quickening occurs |
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-increase in weight -myelination of spinal cord |
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central acidosis stimulates |
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3 vascular shunts that bypass |
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