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Biosystems II
Mitosis
13
Biology
Graduate
02/15/2012

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Term
positive feedback results in
Definition
m-cdk stockpile
Term
who activates condensin?
Definition
m-cdk
Term
prophase
Definition
-chromosomes condense
-nuclear envelope intact
-mitotic spindle assembles
-MT phosphorylated by m-cdk
Term
prometaphase
Definition
-nuclear membrane breaks down
-phosphorylation of lamins by m-cdk
-chromosomes attach to spindle
Term
3 types of MT
Definition
-astral, kinetochore, interpolar
Term
kinetochore
Definition
-multilayered protein that binds to centromeres
-many MT (10-40) per kinetochore
Term
metaphase
Definition
-chromosomes line up in middle of spindle due to growth and shrinkage of MTs and motor proteins
-constant adjustment
-chromosomes held in place under alot of tension
Term
anaphase
Definition
-cohesin linkage broken
-triggered by activation of APC
-each chromatid pulled to pole
Term
anaphase A and B
Definition
-A-shortening of kinetochore MTs
-B- sliding of centromeres
Term
telophase
Definition
-nuclear envelope reassembles
-first cluster around chromosomes to form vesicles
-vesicles fuse to form nuclear envelope
-nuclear pores bring in nuclear proteins and chromosomes decondense
-then we need a lot of protein for transcription/translation
Term
cytokinesis
Definition
-begins during anaphase
-completed when nuclei are formed
-no MTs involved (actin and myosin)
-mitotic spindle dictates where the contractile ring is placed
Term
1st half of mitosis
Definition
m-cdk
Term
2nd half of mitosis
Definition
APC
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