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Small molecule neurotransmitters |
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Acetylcholine Monoamines Amino Acids |
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Neuropeptides (what and where) |
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Two or more amino acids together Released from axon terminal No reuptake/recyclin |
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endogenous opiods oxytocin vasopressin substance p |
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Catecholamines Indolamines |
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Dopamine Epinephrine Norepinephrine |
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CNS: REM Activate Cortex Learning and Memory PNS: Neuromuscular junction Muscle activity Effects: Neocortex hippocampus thalamus amygdala Area released: Basal forebrain pons + midbrain |
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Nicotinic: Ionotropic Found on muscle Stimulated by nicotine generate muscle twitches Muscarinic: metabotropic predominant in CNS - axoaxonic synapses - presynaptic facilitation |
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Nigrostriatal System Mesolimbic System |
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Origin: Substantia nigra Terminals: Striatum Receptors: Metabotropic Function: Control movement,parkinson's disease |
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Origin: Ventral tegmental area Terminals: Limbic system, nucleus accumbens FUnctions: Reward, memory, motivation |
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Dopaminergic Systems in the brain |
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Effects: Frontal lobe, basal ganglia, Amygdala, hippocampus |
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Origin: Locus coeruleus Terminals: Most of the brain Receptors: All metabotropic, respond to both E and NE Functions: vigilance emotions |
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Origin: Raphe nuclei Terminals: Most of the brain Receptors: metabotropic Functions: Mood, sleep, Appetite |
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Major excitatory NT in the CNS Receptor types: Metabotropic glutamate receptors Ionotropic: NMDA, AMPA, Kainate |
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Major inhibitory neuron in the CNS Receptor types: GABAa (ionotropic) GABAb (metabotropic) |
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Diffuses out of cell as soon as it is produced No vesicles No receptors - gets directly into other cells |
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