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connects many non-motor structures with the primary motor cortex via the basal ganglia |
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ventral striatum -highly involved in turning motivation into ACTION -start of motor output of limbic system -approach or avoid NAC ACTIVATED! -rich in dopamine receptors (receives signals from VTA) |
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all things good increase activity in nucleus accumbens -food, water, sex, drugs damage=reduction in eating, drinking, sex, drug-taking (depression=low activity here) |
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Term
dopamine hypothesis of addiction |
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Definition
ability of drugs of abuse to elevate and to sensitize elevation in nucleus accumbens levels of dopamine is responsible for motivation for the effects of the drug! |
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Definition
circuit of inter-connected brain regions -initiation, coordination, and control of motor movements -procedural memory |
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Definition
loss of striatal inhibitory GABA interneurons -hyperactivity of NSDS |
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Definition
loss of SN dopamine neurons |
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