Term
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Definition
| F = (AUC of X / Dose of X ) / (AUC of IV / Dose of IV) |
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Term
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Definition
RBA = (AUC of X / Dose of X ) / (AUC of Reference / Dose of Reference)
RBA = F of X / F of reference |
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Term
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Definition
| K = (solubility in lipid) / (solubility on water) |
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Term
| Ka = (in terms of acids & bases) |
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Definition
Ka = {Base * Proton Concentration) / Acid
Ka = ([A-][H+]) / [HA]
Ka = ([B][H+]) / [BH+] |
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Term
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Definition
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Term
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Definition
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Term
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Definition
dQ/dt = (DAK(change in concentration))/h
Papp=DK/h so...
(dq/dt)/A = Papp(change in concentration) |
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Term
Henderson Hasselback
pH = |
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Definition
pH = pKa + log(base/acid)
pH = pKa + log (A-/HA)
pH = pKa + log (B/BH+) |
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Term
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Definition
| fraction base unionized = B / B + BH+ |
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Term
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Definition
| V = (Vmax[drug])/[drug] + Km |
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Term
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Definition
| dm/dt = (DS/h)(Cs-Ct) = DSCs / h |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| there is an error in the calculation |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| lipid /w lipid, water /w water |
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Term
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Definition
D = diffusion coefficent
A = surface area
K = partition coefficent
h = membrane thickness
Papp = permability coefficent |
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Term
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Definition
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Term
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Definition
| describes the relative abundance of one specie to another |
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Term
| Increases Passive Diffusion Rate |
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Definition
1. Greater concentration gradient
2. iincrease partition coefficent (Papp = DK/h)
3. increase the fraction of unionized drug |
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Term
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Definition
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Term
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Definition
1. ability of carrier transport to move molecules
2. number of transporters
3. number of cells in the membrane |
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Term
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Definition
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Term
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Definition
| So, unionized form, HA or B |
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Term
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Definition
| Smax = Intrinsic Solubility + Ion Solubility |
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Term
| Concentration of the Bulk Solvent |
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Definition
| Total drug dissolved / total volume |
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Term
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Definition
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Term
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Definition
| increasing voscosity, increasing molecule radius, or decreasing the temperature |
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Term
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Definition
| molecules absorb heat while disolving, the temperature of the solvent decreases. can speed up the process by heating the mixture. |
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Term
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Definition
| molecules release heat into the solvent as they dissolve, can cool the solvent to speed up the process |
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Term
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Definition
| more than one crystal form |
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Term
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Definition
| measure of solvents ability to separate ions of electrlytes. increasing the solvent polarity increases the dielectric constant |
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