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Definition
| consists of lipoprotein CM and carriers cholesterol esters |
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Definition
| consists of lipoproteins, LDL,VLDL, and IDL and binds LDL receptor |
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Definition
| contains all the lipoproteins and activates LPL |
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Definition
| contains all the lipoproteins and inhibits LPL |
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Definition
| consists of lipoprotein CM remenants, VLDL, IDL, and binds to remnant receptor |
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Term
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Definition
| consists of the lipoproteins CM and HDL, and activates L-Cat |
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Definition
| binds poorly to receptors homozygous poor clearance of chylomicron remnants and IDL Type III Hyperlipoproteinemia |
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Definition
| associated with increased susceptibility to late onset Alzheimer’s disease |
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Term
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Definition
Assembled in intestinal mucosal cells
Surface Monolayer
Phospholipids (5%), Free Cholesterol (1%), Protein (1%)
Hydrophobic Core
Triglyceride (93%), Cholesteryl Esters (1%) |
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Term
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Definition
| the structural protein of the chylomicron contains the majority of cholesterol (as cholesteryl ester) |
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Definition
| activates lipoprotein lipase which catalyses the hydrolysis of triacylglycerols |
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Term
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Definition
chylomicrons consist of lipoprotein lipase
Extra cellular enzyme
Anchored by _____ _____ to capillary walls ( predominantly of adipose tissue and cardiac and skeletal muscles)
Activated by apo CII |
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Term
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Definition
| the Synthesis of chylomicrons and transfer to luminall surface of capillary is stimulated by _____ |
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Term
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Definition
| which has the higher km; muscle LPL or adipose LPL |
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Definition
| CM loses TG CII LPL activity will no longer be supported. It is ow called a ___ ____ and is destined for the liver |
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Term
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Definition
| Circulating concentrations of ___ triacylglycerol increase after a carbohydrate rich meal |
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Definition
| ApoC’s and ApoE are acquired from ___in circulation |
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Term
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Definition
TAG’s transferred to HDL
In exchange for cholesteryl esters
Mediated by _____
Converted to VLDL remnant (IDL)
Then to LDL |
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Term
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Definition
Primary function transport cholesterol to peripheral tissues
Returns to liver
By binding to LDL receptors apoB100/apoE receptors |
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Term
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Definition
| LDL are taken up by the LDL Receptor into __ ___ ___ |
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Term
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Definition
Increase in free cholesterol decrease cholesterol synthesis and uptake & increase cholesterol esterification
Inhibition of HMG CoA Reductase
Inhibition of synthesis of new LDL receptors
Esterification by Acyl CoA:Cholesterol acyl transferase |
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Term
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Definition
| where is the highest concentration of lipoprotein lipase? |
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Term
| Type II familial hypercholesterolemia |
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Definition
| LDL deficiency is characterized by what disease |
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Term
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Definition
| this enzyme is inhibited by high cholesterol |
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Term
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Definition
| these types of receptors can bind a broad range of ligands and mediate the endocytosis of chemically modified LDL in whith the lipid components or apoB have been oxidized |
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Term
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Definition
| these cells accumulate, releasing growth factors and cytokines that stimulate the migration of smooth muscle cells from the media to the intima. There, they proliferate, produce collagen and take up lipid. |
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Term
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Definition
Smallest of the lipoproteins
Synthesized by intestine and liver as nascent cholesterol-poor lipoprotein
Accumulates cholesterol and cholesteryl esters through interactions with peripheral cells and other lipoproteins
Participates in reverse cholesterol transport, removal of excess cholesterol from peripheral cells and delivery to the liver for metabolism; Serve as circulating reservoir of apoCII and apoE |
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Term
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Definition
| HDL is secreted in a ____ form from the liver and intestine |
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Term
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Definition
| This provides mediated esterification of cholesterol generates spherical particles that continue to grow on ongoing cholesterol esterification HDL2 |
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Term
| reverse cholesterol transport |
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Definition
Transport of cholesterol from tissues to HDL and from HDL to Liver
Mediated by Scavenger receptor class B( SR-BI) |
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Term
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Definition
this inhibit the oxidative modification of LDL, the
Inhibition of adhesion molecules, and the formation of foam cells |
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Term
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Definition
Consist of LDL and a protein designated as (a)
Apo(a) is covalently linked to apoB-100 by a disulfide linkage
Highly homologous to Plasminogen
High risk association with premature coronary artery disease and stroke
Elevated levels of this may slow the break down of clots that trigger MI |
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