Term
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Definition
| >90% of ingested lipids is |
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Term
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Definition
| secreted from glands at back of tongue digests both very slowly: some water-insoluble TAGs are converted to FAs and diacylglycerols stabilizing the solubility of the lipid in an aqueous environment |
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Term
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Definition
is secreted in the stomach; enzyme is active in neutral pH
• Functions for the digestion of (milk) lipids in infants whose stomach pH is close neutrality but
• Virtually no digestion of lipids in adults until small intestine because lipids are not emulsified |
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Term
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Definition
| Emulsification occurs in the |
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Term
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Definition
•Derivatives of cholesterol linked to side chain of glycine or taurine via an amide linkage
•Stabilize lipids preventing coalescing and making smaller particles |
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Term
| Cholecystokinin (CCK or pancreozymin) |
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Definition
is a peptide secreted by duodenum and jejunum mucosal cells
• Secreted in response to lipids in duodenum
• Acts on gall bladder release bile and exocrine cells of pancreas digestive enzymes |
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Term
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Definition
peptide hormone produced by other intestinal cells
in the pancreas to release bicarbonate solution neutralize pH for enzyme activity |
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Term
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Definition
• Triacylglycerides too large for absorption by intestinal villi
Broken by ____ ___ which removes fatty acids at c1 and c3 |
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Term
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Definition
| secreted by pancreas, anchors and stabilizes lipase at lipid-aqueous interface (bonds to both water-lipid interface and to lipase) and helps lipase overcome inhibition by bile acids |
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Term
| Pancreatic cholesteryl ester hydrolase |
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Definition
| cleaves cholesteryl esters to cholesterol and FFAs |
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Term
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Definition
| This enzyme is activated by trypsin and it removes FA at C-2 |
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Term
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Definition
| • FA at C-1 removed by _____to leave a glycerylphosphoryl base (e.g. glycerylphosphorylcholine) excreted in feces, degraded or absorbed |
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Term
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Definition
clusters of amphipathic lipids that coalesce with hydrophobic sides inside and hydrophilic heads outside and
these approach brush border of intestinal mucosal cells and are absorbed |
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Term
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Definition
| FAs are converted into their activated form by |
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Term
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Definition
| becomes essential if linoleic is deficient |
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Term
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Definition
| The diet drug ____ inhibits gastric and pancreatic lipase |
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Term
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Definition
| Lysophospholipids get new FA's from ___ to make phospholipids |
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Term
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Definition
| are released into the lacteals by the enterocytes and are transported via the thoracic duct to the L. subclavian vein |
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Term
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Definition
| this is caused by loss of lipid and fat-soluble vitamins A, D, E and K and essential FAs and results in lipids in feces |
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Term
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Definition
| is essential for chylomicron release from enterocytes |
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Term
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Definition
| can re-esterify FA's to form TAG's |
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Term
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Definition
Consist of cholesteryl esters, phospholipids, apolipoprotein
These bind to receptors on hepatocytes and are endocytosed and hydrolyzed |
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Term
| Familial lipoprotein lipase deficiency |
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Definition
Known also as type I hyperlipoproteinemia
Deficiency of lipoprotein lipase or its coenzyme apo-CII
This leads to chylomicronemia |
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Term
| Type III hyperlipoproteinemia |
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Definition
Known also as familial dysbetalipoproteinemia
Failure of endocytosis of chylomicron remnants
The remnants accumulate in the plasma |
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