Term
| Nutrasweet made up of two aa which are... |
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Definition
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Term
| What causes the formtn of aldol cross-links in collagen |
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Definition
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Term
| AA substtn leading to osteogenesis imperfecta |
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Definition
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Term
| Hydroxylysine formtn requires |
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Definition
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Term
| IgE most likely found on... |
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Definition
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Term
| Alpha helix stabilized by |
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Definition
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Term
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Definition
|
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Term
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Definition
| stabilizing deoxy (T) form of Hb |
|
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Term
| The hydroxylation of proline residues in collagen |
|
Definition
| is a post-translaitonal modification |
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Term
17. The blood plasma protein that specifically binds
Fe+3 is |
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Definition
|
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Term
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Definition
| has a heavy chain N-terminus |
|
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Term
| HbS red blood cells sickle because |
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Definition
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Term
The amino acid sequence, Gly-Leu-Pro-Gly-
HyLys-Pro-Gly-Val-Pro, would most probably be
found in |
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Definition
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Term
CO2 binds to Hb and aids in O2 delivery to the
tissues by |
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Definition
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Term
| The antigen binding sites of immunoglobulins |
|
Definition
| form pockets to fit the antigens |
|
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Term
| The dimeric Ig found in tears |
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Definition
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Term
The Ig that crosses the placenta to protect the
fetus |
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Definition
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Term
| Amino acid converted to desmosine in elastin |
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Definition
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Term
Ca+2 initiates striated muscle contraction by
binding to |
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Definition
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Term
The major protein of thin filaments in striated
muscle is |
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Definition
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Term
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Definition
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Term
| Hemoglobin's binding affinity for O2 |
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Definition
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Term
37. Extracellular matrix proteins include all the
following EXCEPT
A. Laminin
B. Transferrin
C. Fibronectin
D. Type IV collagen
E. Vitronectin |
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Definition
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|
Term
The blood plasma protein NOT made in the liver
GC-globulin
Transferrin
Immunoglobulin M
Albumin
Alpha-1 Antitrypsin |
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Definition
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|
Term
The thermodynamic driving force for the correct
folding of proteins comes from the |
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Definition
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|
Term
When striated muscle contracts, a conformational
change in which protein results in the “power stroke”? |
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Definition
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|
Term
| Carbon monoxide (CO) is a poison because it |
|
Definition
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Term
A methyl group at the no.5 position of which
base distinguishes DNA nucleotides from RNA
nucleotides? |
|
Definition
|
|
Term
Which of the following mutagens is an
intercalating agent? |
|
Definition
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|
Term
During DNA repair, which enzyme uses ATP as a
substrate? |
|
Definition
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|
Term
The C-terminal domain of RNA polymerase II is
activiated by |
|
Definition
|
|
Term
An RNA species found only in eukaryotic
ribosomes is |
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Definition
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|
Term
| Eukaryotic promoters are recognized directly by |
|
Definition
| basal TFs and enhancer binding proteins |
|
|
Term
A novel chemical linkage in eukaryotic mRNA
caps is |
|
Definition
| 5'-5' phosphodiester bond |
|
|
Term
51. Which antimicrobial agent binds to the 30S
ribosomal subunit to inhibit protein synthesis? |
|
Definition
|
|
Term
| Polyadenosine tails in eukaryotic mRNA are |
|
Definition
| important in cytoplasmic mRNA stability |
|
|
Term
| Transposable genetic elements can... |
|
Definition
interrupt genes,
promote their own mobility,
stimulate gene sequence rearrangements,
function through an RNA intermediate. |
|
|
Term
| Magnesium associates with ATP in cells to |
|
Definition
| neturalize two negative charges on phosphate groups |
|
|
Term
55. Synthesis of the dipeptide LEU-TYR requires 20
kcal/ mole of energy. What is the ÄG associated with
the hydrolysis of LEU-TYR at 37° C if ÄS = 10 cal/
mole/ degree? (OEC = 273EK) |
|
Definition
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|
Term
56. If a Ä pH of 2 exists across a biological
membrane, how much free energy could be gained by
the dissipation of the proton gradient at 37° C? (R = 2
cal/ mol/ degree) |
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Definition
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|
Term
| Vitamins are important because they |
|
Definition
| provide cofactors not otherwise available for important enzyme catalyzed reactions |
|
|
Term
The catalytic mechanism of chymotrypsin
includes |
|
Definition
| an unusually reactive serine residue which undergoes transient acylation during catalysis |
|
|
Term
| Chymytrypsin is formed from chymotrypsinogen by... |
|
Definition
|
|
Term
| Serine protease that cleaves prothrombin. |
|
Definition
|
|
Term
Catalyzes formation of the gamma-glutamylepsilon-
lysine bond. |
|
Definition
| Factor XIIIa (transaminidase) |
|
|
Term
Which of the following increases the rate of
blood coagulation? |
|
Definition
|
|
Term
There are many different proteinases in nature,
one feature that they all have in common, however, is
that each |
|
Definition
cleaves an amide bond giving rise to a carboxyl
group and an amino group. |
|
|
Term
| What is responsible for phosphorylation of tau? |
|
Definition
|
|
Term
Excessive phosphorylation of a protein could
result from |
|
Definition
| too little phosphatase activity |
|
|
Term
Regulation of enzyme activity by allosteric
effectors generally involves |
|
Definition
| changes in enzyme conformation summarized as T - R transitions. |
|
|
Term
| Non-competitive inhibition of an enzyme results in |
|
Definition
|
|
Term
| Antithrombin III may be described generally as a |
|
Definition
|
|
Term
A likely agent in the later treatment of the patient
is coumidin or warfarin. Vitamin K-associated
modification of a protein results in an increased ability |
|
Definition
| to bind, by way of Ca 2+ bridges, to phospholipid membranes |
|
|
Term
Modifier proteins affect the activities of specific
enzymes. An example of a modifier protein is |
|
Definition
| Va of the clotting cascade |
|
|
Term
Lead ingestion would cause decreased
hemoglobin because |
|
Definition
| lead inhibits two enzymes of the heme biosynthetic pathway |
|
|
Term
Where in the cell are the enzymes constituting the
heme biosynthetic pathway located? |
|
Definition
| in mitochondria and cytosol |
|
|
Term
| Heme biosynthesis is regulated at the level of |
|
Definition
| delta-amino levulinic acid (ALA) synthase |
|
|
Term
|
Definition
|
|
Term
Bilirubin is normally transported through the
aqueous circulation |
|
Definition
| complexed with serum albumin |
|
|
Term
When compared to the immunoglobulin light (L)
chain genes, an additional degree of diversity in
heavy (H) chain genes is achieved due to: |
|
Definition
| presence of D-region exons |
|
|
Term
|
Definition
|
|
Term
| To measure complexity of a genome: |
|
Definition
|
|
Term
| A sequence unique to human genome |
|
Definition
|
|
Term
E.coli bacteria use the restriction enzyme, EcoRI,
to defend against a bacteriophage infection. The
bacterial DNA is immune to EcoRI cleavage due
to: |
|
Definition
|
|
Term
Identification of the promoter elements of a gene
requires: |
|
Definition
|
|
Term
Site-directed mutagenesis using an
oligonucleotide can be employed to produce: |
|
Definition
| point mutn, insertion, deletion |
|
|
Term
A vector to clone large size (1 mb) fragments of
DNA: |
|
Definition
|
|
Term
| A gel method to detect RNA: |
|
Definition
|
|
Term
A method to detect specific DNA sequences
on chromosomes: |
|
Definition
|
|
Term
| DNA-protein interactions may be studied by: |
|
Definition
| gel mobility shift assays |
|
|
Term
| (SSCP) analysis can be used to detect: |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Major Histocompatibility Complex (MHC) |
|
|
Term
| Ubiquitin is a small protein used to |
|
Definition
| mark proteins for degradation |
|
|
Term
The interaction of transcription factors with
DNA sequences is usually by interactions (major or minor groove?) |
|
Definition
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|
