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Definition
| acetylcholinesterase will hydrolize acetylcholine into this form & choline so not active in synaptic cleft |
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Definition
| introduce an acetyl group into compoundto gain or lose substitution of an acetyl group |
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Definition
| major neurotransmitter, when excess amounts are left in synaptic cleft=slow pulse, low BP, muscle twitching |
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Definition
| hydrolzyes acetylcholine to acetate & choline so no longer active in neuromuscular junct. |
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Term
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Definition
| aspirincovalent acetylation of active site on serine |
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Term
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Definition
| energy necessary to achieve transition state of reaction, determines how fast reaction occurs |
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Definition
| region on surface of enzyme where catalytic reaction occurs |
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Term
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Definition
| groups that are activated when coenzyme A is synthesized from pantothenate |
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Definition
| example of oxidoreductase enzymeNAD+ to NADH |
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Definition
| used to treat goutclosely resembles hypoxanthine, irreversible & suicide inhibitor |
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Term
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Definition
| functional group involved in catalysis of enzymes |
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Definition
| binds to serine active site prostaglandin endoperoxide synthase, inhibits production of prostaglandins |
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Term
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Definition
| activation-transfer coenzyme, carboxylase uses to activate CO2 |
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Term
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Definition
| carbon double bonded to oxygenattacked by H2O in formation of chymotrypsin |
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Term
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Definition
| enzyme that add CO2 to another compound w/ ATPmost require coenzyme biotin |
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Term
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Definition
| rate of enzyme reaction divided by rate of uncatalyzed reaction |
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Term
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Definition
| activation-transfer coenzyme, synthesized from vitamin pantothenic acid (pantothenate) |
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Term
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Definition
| nonprotein organic molecules that help the catalytic reactionusually derived from vitamins |
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Term
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Definition
| anything that binds with an enzyme that helps lower activation energy & catalyze the reaction |
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Term
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Definition
| once formed render enzyme inactiveextremely tight bonds w/ functional groups @ active site |
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Term
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Definition
| oxidoreductase enzymeparticipates in glycine, serine and threonine metabolism |
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Term
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Definition
| enzyme responsible for formation of prostanoidsaspirin inhibits this enzyme to function |
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Term
| DIISOPROPYLPHOSPHOFLUORIDATE- |
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Definition
| (nerve gas) binds to active site w/ covalent bondenzyme cannot function |
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Term
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Definition
| substrates react w/ specific structuresability of enzyme to select substrates |
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Term
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Definition
| major enzyme classreaction where adding H2O produces two compounds |
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Term
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Definition
| (hydrogen w/ 2 electrons) is transferred to NAD+ when lactate or alcohol dehy. oxidize substrates |
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Term
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Definition
| transition state from AMP to urateoxidized by xanthine oxidase |
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Term
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Definition
| conformational change to enzyme & substrate induced by substrate bindingside chains reposition |
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Definition
| compounds that decrease rate of enzymatic reaction |
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Term
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Definition
| major enzyme classrearrange molecules, substrate & product will be isomers |
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Term
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Definition
| heavy metaltoxic because they bind to functional groups of enzymes resulting dysfunctional enzyme |
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Term
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Definition
| specific molecule that binds to the protein formed binding site e.g. ATP, O2 or another protein |
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Term
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Definition
| major enzyme classsynthesizes bonds through cleavage of ATP (C-C, C-S, C-O, C-N) |
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Term
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Definition
| major enzyme classsplits molecules w/out H2O or ATP |
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Term
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Definition
| heavy metaltoxic because they bind to functional groups of enzymes resulting dysfunctional enzyme |
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Term
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Definition
| induced fit or lock-&-keyexplanation for the way a substrate binds to enzyme side chain of AA |
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Term
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Definition
| major enzyme classoxygen-reduction reactions, all dehydrogenases (i.e. NAD+/NADH) |
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Term
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Definition
| generated by the reaction of hydroxylamine and aldehydes or ketones R1R2C=NOH (oxime is a drug given to treat malathion poisoning; it restores activity of acetylcholinesterase inhibited by malathion, if given before the irreversible complex is formed) |
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Term
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Definition
| any cofactor bound tightly to an enzymepermanent (i.e. biotin, heme group) |
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Term
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Definition
| another name for pyridoxinevitamin B6, synthesizes pyridoxal phosphate |
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Term
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Definition
| activation-transfer coenzyme, synthesized from pyridoxine (vitamin B6) |
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Term
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Definition
| is converted to active form, pyridoxal 5-phosphateinhibits formation of glycation endproducts |
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Term
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Definition
| vitamin B6, synthesizes pyridoxal phosphate |
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Term
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Definition
| example of ligase enzyme that uses ATP for hydrolysis |
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Term
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Definition
| can participate in covalent catalysis because of hydroxyl R-group |
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Term
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Definition
| energy required to reach transition state is lowered by enzyme activitybinds tightly to enzyme |
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Term
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Definition
| undergo partial reaction to form irreversible inhibitors @ active sitebinds specifically |
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Term
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Definition
| example of ligase enzyme that uses ATP for hydrolysis |
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Term
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Definition
| common vitamin deficiency in alcoholicsneed to receive from diet, increases energy levels |
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Term
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Definition
| activation-transfer coenzyme, synthesized from vitamin thiamine |
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Term
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Definition
| types of bonds formed by sulfhydryl group on coenzyme A |
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Term
| TRANSITION STATE ANALOGUE- |
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Definition
| extremely potent & specific inhibitorresemble intermediate stage of reaction |
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Term
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Definition
| major enzyme classtransfer of different groups (i.e. phospate from ATP to another molecule) |
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Term
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Definition
| result of degradation of purine nucleotides AMP & GMP (uric acid) |
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Term
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Definition
| insoluble deposits that lead to gout in joints & big toeallopurinol suicide inhibitor to prevent |
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Term
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Definition
| pyridoxine, synthesizes pyridoxal phosphate |
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Term
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Definition
| intermediate in degradation pathway of purine nucleotidesoxidized from hypoxanthine |
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Term
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Definition
| oxidoreductase reaction of xanthine & hypoxantine to urate |
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Term
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Definition
| normal function convert hypoxanthine to xanthine then urateinvolved in degrading purine |
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