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Biochem Quiz 1-d
Protein Synthesis and Modification
25
Biology
Professional
08/30/2009

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Cards

Term
Mechanisms for Controlling Translation Initiation -- Eukaryotes
Definition
Phosphorylation of eIF-2, Regulation of eIF-4e with 4E-BP, mRNA masking
Term
Controlling Elongation -- Eukaryotes
Definition
ADP Ribosylation (diphtheria toxin)
Term
Puromycin
Definition
Eukaryotes/Prokaryotes, Premature Termination, bins to A site
Term
Cycloheximide
Definition
Eukaryotes, Inhibits peptidyl transferase (60S Sub)
Term
Chloramphenicol
Definition
Prokaryotes/Mitochondria, Inhibits peptidyl transferase (50S Sub)
Term
Streptomycin
Definition
Prokaryotes, causes mRNA misreading (30S Sub)
Term
Tetracycline
Definition
Prokaryotes, blocks incoming AA-tRNA, 30S Sub
Term
Erythromycin
Definition
Prokaryotes, Blocks exit tunnel, 50S subunit
Term
Post-translational targeting
Definition
Mitochondria, Nucleus, Peroxisomes
Term
ER Resident Proteins
Definition
KDEL sequence
Term
Secreted Proteins
Definition
prosequence, SRP receptor
Term
Integral Proteins
Definition
Stop transfer sequence. Default = plasma membrane
Term
Lysosomes
Definition
Glycosylation, phosphorylation...then in clathrin coated vesicles with low pH, where Phos and Glyc removed
Term
I-Cell Disease
Definition
Lysosomal storage disease, No phosphotransferase
Term
Human Deafness Dystonia
Definition
TIM complex mutation (mitochondrial)
Term
Peroxisome localization
Definition
SKL sequence
Term
Zellweger's Syndrome
Definition
Peroxisome mutation
Term
O-Glycosylation
Definition
gOlgi
Term
N-glycosylation
Definition
eNdoplasmic reticulum
Term
Lysosomal degradation
Definition
non-selective, cathepsin, extracellular proteins
Term
Cytosolic degradation
Definition
selective, ubiquitin mediated degradation
Term
Lysosomal degradation
Definition
non-selective, cathepsin, extracellular proteins
Term
Cytosolic degradation
Definition
selective, ubiquitin mediated degradation, proteosome
Term
Collagen Mutation Clinical Examples
Definition
Osteogenesis Imperfecta, Ehler-Danlos Syndrome, Scurvy
Term
Scurvy
Definition
Vitamin C deficiency
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