Term
| What are the two main amino sugars that make up glucosaminoglycans? |
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Definition
- N-Acetylglucosamine
- N-Acetylgalactosamine
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Term
| What are the two main uronic acid components that make up GAG's? |
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Definition
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Term
Do GAG's have a negative or a positive charge?
From this, what do they attract? |
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Definition
Negative
Attract water and Sodium |
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Term
| Progeria is caused by a lack of what GAG? |
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Definition
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Term
| What disaccharide makes up hylauron? |
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Definition
Glucouronate and N-Acetylglucosamine |
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Term
| What GAG is used as a space filler in early embryos and resists compression in adults? |
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Definition
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Term
| True or False: Hyaluronan is not bound to a protein? |
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Definition
TRUE.
Hyaluronan is a "stand alone" GAG. |
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Term
| What is the most common GAG and what can it bind to? |
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Definition
| Chondroitin Sulfate, binds to collagen |
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Term
What end of Chondroitin Sulfate is epimerized to form Dermatan Sulfate?
It goes from ____ to ____ |
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Definition
The Carboxyl end
goes from Glucouronate to Iduronate |
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Term
| What GAG has the most Sulfate? |
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Definition
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Term
| Where can Sulfates be added on to GAGs? |
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Definition
N-acetyl group
Carbon 6 of the glucosamine
Carbon 2 of the glucuronate
replace carboxyl carbon on iduronate |
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Term
The highly negative charge of heparin allows it to bind to ____. |
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Definition
Antithrombin III
Which allows for it to have an important in anticoagulant effect
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Term
| What GAGs has only Alpha-1-4 bonds? |
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Definition
| Heparin and Heparan Sulfate |
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Term
| What GAG is comprised of galactose and N-acetylglucosamine? |
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Definition
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Term
| Keratan Sulfate is most abundant in what? |
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Definition
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Term
Where is the core protein of proteoglycan synthesized? |
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Definition
Rough Endplasmic Reticulum |
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Term
| Where are the GAGs assembled on to the core protein? |
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Definition
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Term
What enzyme adds sugars to the core protein of proteoglycans? |
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Definition
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Term
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Definition
A proteoglycan that is predominant in cartilage. It contains over 100 GAGs |
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Term
| Decorin is a proteoglycan that contains how many GAGs? |
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Definition
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Term
What proteoglycan can be found in the basal lamina and functions for structure and filtering? |
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Definition
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Term
Serglycin is found where? And does what? |
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Definition
a proteoglygan
Found in secretory vesicles
Packages and stores secretory molecules |
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