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Biochem block 3, wk 1- Lipids
Med school biochem
20
Biochemistry
Graduate
10/18/2010

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Term
Characterizes Phosphatidic acid
Definition
Saturated FA at C1 of glycerol and unsaturated at C2
Term
Characterizes ether phospholipids
Definition
Ether linkage at C1
Term
Characterizes platelet activating factor (PAF)
Definition
acetyl residue at C2
Term
Characterizes plasmalogens
Definition
Contain an alpha, beta- unsaturated ether at C1
Term
Phospholipase A1
Definition
cleaves FA from C1
Term
Phospholipase A2
Definition
cleaves FA from C2
Term
Phospholipase C
Definition
Cleaves C3 phosphodiester bond closer to glycerol backbone. Produces diacylglycerol
Term
Phospholipase D
Definition
Cleaves C3 phosphodiester bond farther from glycerol to produce phosphatidic acid
Term
Function of Prostacyclin (PGI2)
Definition
Vasorelaxant and platelet declumping
Term
Function of Prostoglandin E2 (PGE2)
Definition
Fever and pain
Term
Function of Thromboxane A2
Definition
Vasoconstriction and platelet aggregation
Term
Lipoxygenase
Definition
catalyzes addition of one O2 to arachidonic acid
Term
Cyclooxygenase
Definition
catalyzes addition of two O2 to arachidonic acid
Term
Characterizes sphingolipids
Definition
do not contain glycerol, instead comprised of the long-chain alcohol called sphingosine
Term
Sphingomyelin
Definition
Contains phosphocholine or phosphoethanolamine as polar head group
Term
Glycosphingolipids
Definition
Have one or more sugars connected directly to hydroxyl group at C1 of ceramide. Neutral at pH 7
Term
Ganglioside
Definition
Polar head groups of oligosaccharides with one or more N-acetylneuraminic acid (NANA) at the termini. Negative at pH 7
Term
Sphingosine is made from?
Definition
Palmitoyl CoA and serine
Term
Characterizes polyisoprenoids
Definition
Class of lipids differs from others in that they are derived from 5-carbon isoprene units, rather than FA's
Term
Characterizes steroids
Definition
basic 4 ring structure that is synthesized from squalene
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