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biochem 2review mahfouz test 2
biochem review for mahfouz's second test
70
Chemistry
Undergraduate 2
02/04/2009

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Term
Phosphatidic acid yields
Definition
PI, PC, and DPG
Term
palmitoyl CoA and serine are biosynthesized from
Definition
Ceramides
Term
Ceramide yeilds...
Definition
sphingomyelin, gangliosides, and cerebrosides
Term
cholesterol yields...
Definition
bile salts or steroids
Term
acetyl CoA yields...
Definition
cholesterol and other steroids
Term
cholesterol yields...
Definition
progesterone, mineralocorticoids, glucocorticoids, androgens and estrogens
Term
beta-carotene yields
Definition
vitamin A
Term
C20 polyunsaturated fatty acids (Ex archidonic acid) yield
Definition
eicosanoids (leukotrienes, PGH2, thromboxanes, prostacyclin and other prostaglandins)
Term
phospholipase A2 is inhibited by (PGH2 synthase is inhibited by)
Definition
cortisone (NSAIDS)
Term
trypsin and chemotrypsin
Definition
breakdown polypeptides into amino acids
Term
cathepsins
Definition
are hydrolytic enzymes in the lysosome
Term
KFERQ
Definition
the selectively degraded proteins bh the lysosome
Term
Glu Dehydrogenase is inhibited by and activated by
Definition
GTP and NADH, and ADP and NAD+ (respectively)
Term
Aspartate yields...
Definition
urea and fumarate
Term
Carbamoyl phosphate synthetase 1 is... while 2 is...
Definition
is mitochondrial...cytoplasmic and uses gln to form pyrimidines
Term
CPSII is inhibited by...
Definition
UTP
Term
CPSI is activated by
Definition
N-acetylglutamate
Term
Pyridoxal phosphate (PP)
Definition
cofactor in all transamination reactions
Term
folate enzymes
Definition
are essential for DNA biosynthesis
Term

 

 DHFR inhibited by

Definition
folate structural analogues
Term
Cobalamine
Definition
Cofactor for methyl group transfer and isomerization by transfer of 2 adjacent carbon groups
Term
pyruvate yields
Definition
alanine
Term
oxaloacetate yields
Definition
aspartate and asparagine
Term
a-ketoglutarate yields
Definition
glutamate and glutamine
Term
Glutamate yields
Definition
proline and arginine
Term
Callogen biosynthesis cofactors
Definition
Vitamin C and Fe2+
Term
Arginine yields
Definition
creatinine and nitric oxide
Term
Serine yields
Definition
glycine, purine nucleotides, sphigoliphids and phospholipids, pyruvate, cysteine, and CH2=THF
Term
Glycine yields
Definition
Serine, purine nucleotides, glutatione, porphyrins, creatine phosphate and CH2=THF
Term
methionine yields
Definition
cysteine and a=ketobutyrate
Term
cys yields
Definition
bile acids
Term
Essential amino acids
Definition
leucine, isoleucine, valine, phenylalanine, tryptophan, arginine, histidine, lysine, methionine, and threonine
Term
ASP yields
Definition
lysine threonine and methionine
Term
pyruvate yields
Definition
valine isoleucine and leucine
Term
PEP yields
Definition
phenylalanine, tryptophan and tyrosine
Term
PRPP yields
Definition
histidine
Term
tyrosine yields
Definition
dopamine, epinephrine, norepinephrine and thyroxine
Term
trp yields
Definition
serotonin
Term
histidine yields
Definition
histamine
Term
glycine and glutamate yield
Definition
cobalamines and Heme
Term
Heme is cofactor for
Definition
cytrochromes and hemoglobin
Term
Ala synthase is
Definition
the regulation point in heme synthase
Term
heme
Definition
is the inhibitor, synthesis inhibitor, and transport inhibitor of ALA synthase
Term
pyruvate is yielded by
Definition
alanine, serine, glycine, tyreonine, and cystine
Term
oxaloacetate is produced by
Definition
Asparagine turning into aspartate turning into oxaloacetate
Term
A-ketoglutarate is produced by
Definition
Gln, Argenine, proline, histidine, and Glu
Term
Val yields
Definition
Porpionyl CoA
Term
Ile yields
Definition
propionyl CoA and acetyl CoA
Term
Leu yields
Definition
Acetyl CoA and acetoacetyl CoA
Term
Methionine yields
Definition
cysteine, propionyl CoA and succinyl CoA
Term
Lysine yields
Definition
acetoacetyl CoA
Term
trp yields
Definition
alaine, acetoacetyl CoA and NAD and NADP
Term
Phe and tyr yield
Definition
fumarate and acetoacetate
Term
PKU is
Definition
a genetic disease resulting in too little phenylalanine hydroxylase, resulting in high levels of phenylpyruvate from phenylalanine.  Mental retardation happens in a few months without treatment, and patients should have low Phe diets.  Disappears after 10 years of age.
Term
nucleotidases
Definition
turn nucleotides into nucleosides for transport from GI to circulation
Term
Pentose + aromatic base yields
Definition
nucleotides
Term
PRPP amidotransferase is inhibited by
Definition
AMP and GMP
Term
Guanylate kinase turns
Definition
GMP into GDP
Term
NDP kinase turns
Definition
GDP into GTP
Term
Adenylate kinase turns
Definition
AMP into ADP
Term
AMP yields... which is acted on by... and turned into .... which is the product of.... which is then acted on by... to form uric acid
Definition
Hypoxoanthine, xanthine oxidase, xanthine, GMP, xanthine oxidase
Term
Gout is caused by
Definition
increased concentration from uric acid (caused by excessive synthesis of purine nucleotides or impared excretion by kidneys)
Term
Carbamoyl phosphate synthetase II is inhibited by and activated by
Definition
UTP -- ATP and PRPP resepectively
Term
CTP synthetase is activated by and inhibited by
Definition
GTP and CTP respectively
Term
adrenaline and noradrenaline are synthesized from
Definition
tyrosine
Term
Adrenocorticalsteroids are synthesized from
Definition
cholesterol
Term
Phosphodiestrase
Definition
converts cAMP to linear AMP
Term
CA++ and IP3
Definition
are csecond messengers for type 3 receptors
Term
the second messenger for type 4 is
Definition
diacylglycerol DAG
Term
Steroid hormones
Definition
stimulate expression of certain genes by making more mRNA
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